Is CI 73000 safe in cosmetics?
CI 73000 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted.
MODERATE
Cosmetic Ingredient
CI 73000
Also known as: C.I Vat Blue 1, C.I. 73000, 2-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,2- dihydro-3H-indol-3-one, 2-(3-Oxo-1,3-dihydro-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one, 11669 Blue (+15 more)
CI 73000 (CAS 482-89-3) is a cosmetic cosmetic ingredient functioning as Colorant. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Colorant
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2-(3-hydroxy-1H-indol-2-yl)indol-3-one
InChIKey
QQILFGKZUJYXGS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
FDA permanently listed as D&C Blue No. 6 (21 CFR 73.3119, 74.1109) for use in surgical sutures only (collagen, polypropylene, polydioxanone sutures) with strict concentration limits (0.2–0.5%); not approved for general cosmetic use; EU-regulated under Annex IV
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 73000.
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Assessment Under Re-Verification
A margin-of-safety result previously shown for CI 73000 has been withdrawn pending re-verification. We don't display safety verdicts we can't fully substantiate from the primary SCCS source — so this entry is being re-checked rather than shown unverified.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Blue
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Surface modifier
Editorial summary
Preliminary editorial summary for CI 73000 — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
not-for-general-cosmetics
fda-device-sutures-only
natural-origin
vat-dye
regulatory-verification-needed
Known Synonyms
C.I Vat Blue 1
C.I. 73000
2-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,2- dihydro-3H-indol-3-one
2-(3-Oxo-1,3-dihydro-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one
11669 Blue
2,2'-Bis(2,3-dihydro-3-oxoindolylidene)
Bezema Indigo AXX-FL
C.I. Natural Blue 1
D+C Blue No. 6
Dystar Indigo Gr
Indigo Powder W
Indigotin (natural)
Japan Blue 201
Natural Blue 1
Reduced Dark Blue VB
Vat Dark Blue VB
Indigotine
C Blue 22
Vat Blue 1
3H-Indol-3-one, 2-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro-(Indigo Blue)
Chemical Function
Dye
Surface modifier
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Medical/dental
Europe; Other direct contact consumer goods; residue
Environmental Research
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Indigo naturalis (plant-derived)
Food Category
colorant
Frequently Asked Questions
Is CI 73000 allowed in the EU?
CI 73000 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 73000 do in cosmetics?
CI 73000 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 482-89-3.
Is CI 73000 used outside cosmetics?
CI 73000 also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 73000 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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