CI 73000

CAS Number
482-89-3
Function
Colorant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes FDA permanently listed as D&C Blue No. 6 (21 CFR 73.3119, 74.1109) for use in surgical sutures only (collagen, polypropylene, polydioxanone sutures) with strict concentration limits (0.2โ€“0.5%); not approved for general cosmetic use; EU-regulated under Annex IV

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Natural indigo blue pigment (D&C Blue No. 6) with FDA approval limited to surgical sutures only; not cleared for general cosmetic use and restricted under EU Annex IV; regulatory confirmation required before cosmetic formulation.

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Concern Level: Moderate

Regulatory Flags

not-for-general-cosmetics fda-device-sutures-only natural-origin vat-dye regulatory-verification-needed

Frequently Asked Questions

Is CI 73000 safe in cosmetics?

Natural indigo blue pigment (D&C Blue No. 6) with FDA approval limited to surgical sutures only; not cleared for general cosmetic use and restricted under EU Annex IV; regulatory confirmation required before cosmetic formulation. The EU classifies CI 73000 as "restricted". Safety rating: MODERATE.

Is CI 73000 allowed in the EU?

CI 73000 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 73000 do in cosmetics?

CI 73000 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 482-89-3.

What is the Margin of Safety for CI 73000?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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