What is the NOAEL for Biochanin A?
Biochanin A has 14 NOAEL studies in the database. The lowest reported value is 1.85317832463126 uM. Source: NTP_ICE_endocrine.
NOAEL Data
Cosmetic Ingredient
Biochanin A
Also known as: EINECS 207-744-7, UNII-U13J6U390T, 5,7-Dihydroxy-4'-methoxy-Isoflavone, 5,7-Dihydroxy-4'-methoxy-Isoflavone (8CI), 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one (+3 more)
CAS 491-80-5
Biochanin A (CAS 491-80-5) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Biochanin A
CAS Number
491-80-5
DTXSID
DTXSID1022394
Molecular Formula
C16H12O5
InChI Key
WUADCCWRTIWANL-UHFFFAOYSA-N
Monoisotopic Mass
284.068473
Synonyms
EINECS 207-744-7UNII-U13J6U390T5,7-Dihydroxy-4'-methoxy-Isoflavone5,7-Dihydroxy-4'-methoxy-Isoflavone (8CI)5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one5,7-dihydroxy-3-p-methoxyphenyl-4H-chromen-4-oneBiochanine apratensol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
HumectantSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 4.04294328999697 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 1.85317832463126 | uM | ACC | - | - | NTP_ICE_endocrine |
| 230 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| U13J6U390T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U13J6U390T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U13J6U390T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U13J6U390T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0203 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =2.5 | mg/day | LEL | oral | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| =3 | mg | LEL | oral | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| =5.9 | mg | LEL | oral | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| =9.2 | mg | LEL | oral | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.356 | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 14 of 14 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BIOCHANIN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
7
Frequently Asked Questions
What regulatory lists include Biochanin A?
Biochanin A appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Biochanin A used in cosmetics?
Yes, Biochanin A is also indexed as a cosmetic ingredient under the name Biochanin A. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Biochanin A come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Biochanin A used outside industrial chemicals?
Biochanin A also appears in cosmetics, pharmaceutical databases.