What is the NOAEL for Ethanol, 2-[(2-nitrophenyl)amino]-?
Ethanol, 2-[(2-nitrophenyl)amino]- has 20 NOAEL studies in the database. The lowest reported value is 50 mg/kg bw/d via oral in rat. Source: Regulatory source.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethanol, 2-[(2-nitrophenyl)amino]-
Also known as: EINECS 225-555-8, UNII-9FVT2KMV9O
CAS 4926-55-0
Ethanol, 2-[(2-nitrophenyl)amino]- (CAS 4926-55-0) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
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NOAEL studies
NOAEL studies
20
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
7 fields
Name
Ethanol, 2-[(2-nitrophenyl)amino]-
CAS Number
4926-55-0
Molecular Formula
C8H10N2O3
InChI Key
LFOUYKNCQNVIGI-UHFFFAOYSA-N
Monoisotopic Mass
182.069142
Synonyms
EINECS 225-555-8UNII-9FVT2KMV9O
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 50 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 9FVT2KMV9O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.05 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =0.08 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| ~50 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =50 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =99.88 | % | NOAEL | oral | rat | SCCS Opinion |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =500 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =600 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =625 | mg/kg bw | NOAEL | oral | rat | SCCS Opinion |
| =0.05 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| =0.08 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| =50 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| 500 | mg/kg bw/d | developmental toxicity | oral | rat | Regulatory source |
| 50 | mg/kg bw/d | repeated dose toxicity | oral | rat | Regulatory source |
| 99.88 | % | repeated dose toxicity | oral | rat | Regulatory source |
| 500 | mg/kg bw/d | repeated dose toxicity | oral | rat | Regulatory source |
| 625 | mg/kg bw | repeated dose toxicity | oral | rat | Regulatory source |
Showing 20 of 20 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-[(2-nitrophenyl)amino]ethanol | 225-555-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
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SCCS Opinion
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1407/11 | 21 September 2010 | safe | 3.0% | secondary amine; nitrosamine <50ppb; sensitisation not excluded |
| SCCS/1309/10 | 2010-09-21 | Based on the data provided, the SCCS is of the opinion that the use of HC Yellow n° 2 with a maximum on-head concentration of 0.75% in oxidative and of 1.0% in non-oxidative hair dye formulations does not pose a risk to the health of the consumer. | 0.75% on-head (oxidative); 1.0% on-head (non-oxidative) | A possible sensitising potential cannot be excluded. Secondary amine prone to nitrosation/nitrosamine formation; must not be used with nitrosating substances; nitrosamine content < 50 ppb. |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
1.0%
Category
Colorant
Frequently Asked Questions
What regulatory lists include Ethanol, 2-[(2-nitrophenyl)amino]-?
Ethanol, 2-[(2-nitrophenyl)amino]- appears on 2 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring. Source: EPA CPDat.
Is Ethanol, 2-[(2-nitrophenyl)amino]- used in cosmetics?
Yes, Ethanol, 2-[(2-nitrophenyl)amino]- is also indexed as a cosmetic ingredient under the name HC Yellow No. 2. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethanol, 2-[(2-nitrophenyl)amino]- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Ethanol, 2-[(2-nitrophenyl)amino]- used outside industrial chemicals?
Ethanol, 2-[(2-nitrophenyl)amino]- also appears in cosmetics databases.