NOAEL Data REACH Registered Cosmetic Ingredient

Ethanol, 2-[(2-nitrophenyl)amino]-

Also known as: EINECS 225-555-8, UNII-9FVT2KMV9O

CAS 4926-55-0

Ethanol, 2-[(2-nitrophenyl)amino]- (CAS 4926-55-0) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for HC Yellow No. 2 →

SOURCE noael studies public
NOAEL studies
46
SOURCE chemical inventory jurisdictions
Regulatory lists
3
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields
Name
Ethanol, 2-[(2-nitrophenyl)amino]-
CAS Number
4926-55-0
DTXSID
DTXSID0063650
Molecular Formula
C8H10N2O3
InChI Key
LFOUYKNCQNVIGI-UHFFFAOYSA-N
Monoisotopic Mass
182.069142
Synonyms
EINECS 225-555-8UNII-9FVT2KMV9O

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 46 of 46 studies
ValueUnitEndpointRouteSpeciesSource
50mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
9FVT2KMV9OUNIIFDA UNII substance identifier--openFDA substances
9FVT2KMV9OUNIIFDA UNII substance identifier--openFDA substances
9FVT2KMV9OUNIIFDA UNII substance identifier--openFDA substances
9FVT2KMV9OUNIIFDA UNII substance identifier--openFDA substances
5mg/kg bw/dayLOAELoralratCOSMOS_DB
=0.05mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.05mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.05mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.05mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.08mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.08mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.08mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.08mg/kg bw/dNOAELoralratSCCS_vision_codex
~50mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=50mg/kg bw/dNOAELoralratSCCS_vision_codex
=50mg/kg bw/dNOAELoralratSCCS_vision_codex
=50mg/kg bw/dNOAELoralratSCCS_vision_codex
=50mg/kg bw/dNOAELoralratSCCS_vision_codex
=99.88%NOAELoralratSCCS_vision_codex
=99.88%NOAELoralratSCCS_vision_codex
=99.88%NOAELoralratSCCS_vision_codex
=99.88%NOAELoralratSCCS_vision_codex
=500mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=500mg/kg bw/dNOAELoralratSCCS_vision_codex
=500mg/kg bw/dNOAELoralratSCCS_vision_codex
=500mg/kg bw/dNOAELoralratSCCS_vision_codex
=500mg/kg bw/dNOAELoralratSCCS_vision_codex
=600mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=625mg/kg bwNOAELoralratSCCS_vision_codex
=625mg/kg bwNOAELoralratSCCS_vision_codex
=625mg/kg bwNOAELoralratSCCS_vision_codex
=625mg/kg bwNOAELoralratSCCS_vision_codex
=0.05mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.08mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=50mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=50mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=50mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=50mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
500mg/kg bw/ddevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
500mg/kg bw/ddevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/drepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
99.88%repeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
500mg/kg bw/drepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
500mg/kg bw/drepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
625mg/kg bwrepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 46 of 46 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-[(2-nitrophenyl)amino]ethanol225-555-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1407/1121 September 2010safe3.0%secondary amine; nitrosamine <50ppb; sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
1.0%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for Ethanol, 2-[(2-nitrophenyl)amino]-?

Ethanol, 2-[(2-nitrophenyl)amino]- has 46 NOAEL studies in the database. The lowest reported value is 50 mg/kg bw/d via oral in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include Ethanol, 2-[(2-nitrophenyl)amino]-?

Ethanol, 2-[(2-nitrophenyl)amino]- appears on 2 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring. Source: EPA CPDat.

Is Ethanol, 2-[(2-nitrophenyl)amino]- used in cosmetics?

Yes, Ethanol, 2-[(2-nitrophenyl)amino]- is also indexed as a cosmetic ingredient under the name HC Yellow No. 2. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ethanol, 2-[(2-nitrophenyl)amino]- come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is Ethanol, 2-[(2-nitrophenyl)amino]- used outside industrial chemicals?

Ethanol, 2-[(2-nitrophenyl)amino]- also appears in cosmetics databases.