Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for HC Yellow No. 2. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 5 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | ca.50 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 600 mg/kg bw/day | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for HC Yellow No. 2 based on clinical patch test studies and IFRA standards.
Source: SCCS; IVDK
Expert Verdict
Concentration-dependent sensitization risk; mandatory caution labeling and patch test in US; EU restricts to non-oxidative use only
Regulatory Flags
Frequently Asked Questions
Is HC Yellow No. 2 safe in cosmetics?
Concentration-dependent sensitization risk; mandatory caution labeling and patch test in US; EU restricts to non-oxidative use only The EU classifies HC Yellow No. 2 as "restricted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is HC Yellow No. 2 allowed in the EU?
HC Yellow No. 2 EU regulatory status: restricted. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Yellow No. 2 do in cosmetics?
HC Yellow No. 2 functions as: Hair Dyeing (non-oxidative semi-permanent). It is classified as a cosmetic ingredient in our database. CAS number: 4926-55-0.
What is the Margin of Safety for HC Yellow No. 2?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for HC Yellow No. 2?
The NOAEL (No Observed Adverse Effect Level) for HC Yellow No. 2 is 5 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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