Is HC Yellow No. 2 safe in cosmetics?
HC Yellow No. 2 has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Yellow No. 2
Also known as: EINECS 225-555-8, UNII-9FVT2KMV9O
INCI: HC YELLOW NO. 2
HC Yellow No. 2 (CAS 4926-55-0) is a cosmetic cosmetic ingredient functioning as Hair Dyeing (non-oxidative semi-permanent). NOAEL 325 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 1.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
Function
Hair Dyeing (non-oxidative semi-permanent)
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2-(2-nitroanilino)ethanol
InChIKey
LFOUYKNCQNVIGI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
1.0%
US US Status
permitted
US Notes
Permitted under coal-tar hair dye exemption (FD&C Act §601(a)); CIR safe ≤3%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Yellow No. 2.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Yellow No. 2. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.05 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.08 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.08 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.08 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.08 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =50 mg/kg bw/d | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =50 mg/kg bw/d | oral | rat | NOAEL study | SCCS Opinion |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for HC Yellow No. 2 across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for HC Yellow No. 2 based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: SCCS; IVDK
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products. Max: (b) 1,0%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 1,0%
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 3 | Non-oxidative hair dye (direct) |
| BR | permitted_hair_dye | - | Direct hair dye |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for HC Yellow No. 2 — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Yellow No. 2 by CAS number or substance name.
Studies
22
Lowest NOAEL
0.05
Highest NOAEL
625
Units vary across source rows: mg/kg bw/d, mg/kg bw/day, mg/kg bw
SCCS Opinion
ECHA
Known Synonyms
EINECS 225-555-8
UNII-9FVT2KMV9O
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed
Frequently Asked Questions
Is HC Yellow No. 2 allowed in the EU?
HC Yellow No. 2 EU regulatory status: restricted. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Yellow No. 2 do in cosmetics?
HC Yellow No. 2 functions as: Hair Dyeing (non-oxidative semi-permanent). It is classified as a cosmetic ingredient in our database. CAS number: 4926-55-0.
What is the NOAEL for HC Yellow No. 2?
The NOAEL (No Observed Adverse Effect Level) for HC Yellow No. 2 is =0.05 mg/kg bw/d based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Is HC Yellow No. 2 used outside cosmetics?
HC Yellow No. 2 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check HC Yellow No. 2 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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