What is the NOAEL for 3,4-Diaminotoluene?
3,4-Diaminotoluene has 9 NOAEL studies in the database. The lowest reported value is 8.27 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3,4-Diaminotoluene
Also known as: 1,2-Benzenediamine, 4-methyl-, 4-13-00-00260, BRN 0507965, EINECS 207-826-2, 3,4-Toluylenediamine (+1 more)
CAS 496-72-0
3,4-Diaminotoluene (CAS 496-72-0) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
3,4-Diaminotoluene is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H302, H312, H315, H317, H319, H332, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
3,4-Diaminotoluene
CAS Number
496-72-0
DTXSID
DTXSID9024930
Molecular Formula
C7H10N2
InChI Key
DGRGLKZMKWPMOH-UHFFFAOYSA-N
Monoisotopic Mass
122.084398
Synonyms
1,2-Benzenediamine, 4-methyl-4-13-00-00260BRN 0507965EINECS 207-826-23,4-ToluylenediamineUNII-OE7HJ54P5C
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8.27 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| OE7HJ54P5C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OE7HJ54P5C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OE7HJ54P5C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OE7HJ54P5C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =0.32 | mg/kg bw/day | NOAEL (HED) | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| =0.0001 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.001 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-methyl-o-phenylenediamine | 207-826-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1319452
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 3,4-Diaminotoluene?
3,4-Diaminotoluene appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is 3,4-Diaminotoluene used in cosmetics?
Yes, 3,4-Diaminotoluene is also indexed as a cosmetic ingredient under the name Toluene-3,4-Diamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3,4-Diaminotoluene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 3,4-Diaminotoluene have different safety status in cosmetics vs industrial chemicals?
3,4-Diaminotoluene is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H302, H312, H315, H317, H319, H332, H335).
Is 3,4-Diaminotoluene used outside industrial chemicals?
3,4-Diaminotoluene also appears in cosmetics, pharmaceutical databases.