Is Toluene-3,4-Diamine safe in cosmetics?
Toluene-3,4-Diamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
Toluene-3,4-Diamine
Also known as: 1,2-Benzenediamine, 4-methyl-, 4-13-00-00260, BRN 0507965, EINECS 207-826-2, 3,4-Toluylenediamine (+1 more)
INCI: TOLUENE-3,4-DIAMINE
Toluene-3,4-Diamine (CAS 496-72-0) is a cosmetic cosmetic ingredient functioning as Hair dye intermediate (historically used). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 496-72-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Toluene-3,4-Diamine is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H302, H312, H315, H317, H319, H332, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dye intermediate (historically used)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
4-methylbenzene-1,2-diamine
InChIKey
DGRGLKZMKWPMOH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not approved for cosmetic use; not included in FDA positive lists
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Toluene-3,4-Diamine.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1313
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1313
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A POTENT SKIN SENSITIZER. /PHENYLENEDIAMINE/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Toluene-3,4-Diamine.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
1,2-Benzenediamine, 4-methyl-
4-13-00-00260
BRN 0507965
EINECS 207-826-2
3,4-Toluylenediamine
UNII-OE7HJ54P5C
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1319452
Frequently Asked Questions
Is Toluene-3,4-Diamine allowed in the EU?
Toluene-3,4-Diamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Toluene-3,4-Diamine do in cosmetics?
Toluene-3,4-Diamine functions as: Hair dye intermediate (historically used). It is classified as a cosmetic ingredient in our database. CAS number: 496-72-0.
Is Toluene-3,4-Diamine used outside cosmetics?
Toluene-3,4-Diamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Toluene-3,4-Diamine have different safety status in cosmetics vs industrial chemicals?
Toluene-3,4-Diamine is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H302, H312, H315, H317, H319, H332, H335).
Compliance Tools
Check Toluene-3,4-Diamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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