Also known as: Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Carbamidine hydrochloride, EINECS 200-002-3, Iminourea hydrochloride (+3 more)
CAS 50-01-1
Guanidine monohydrochloride (CAS 50-01-1) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H315; H319. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
Guanidine monohydrochloride is prohibited in EU cosmetics at max 7% but has active industrial GHS classifications (H302, H315, H319).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Skin Irrit. 2; Eye Irrit. 2 | H302; H315; H319 | GHS07 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and skin. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
Industrial and product-use categories associated with this substance.
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3YQC9ZY4YB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3YQC9ZY4YB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3YQC9ZY4YB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3YQC9ZY4YB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =474 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =475 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =556 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =773 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =907 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1120 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =25 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =350 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =0.02 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 15 of 15 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Guanidinium chloride | 200-002-3 | ECHA overview → |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Guanidine monohydrochloride (CAS 50-01-1) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Irrit. 2; Eye Irrit. 2 with signal word Warning. Hazard statements: H302; H315; H319. Source: EU CLP Annex VI (ECHA).
Guanidine monohydrochloride has 15 NOAEL studies in the database. The lowest reported value is 3.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Yes, Guanidine monohydrochloride is also indexed as a cosmetic ingredient under the name Guanidine Hydrochloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Guanidine monohydrochloride is prohibited in EU cosmetics at max 7% but has active industrial GHS classifications (H302, H315, H319).
Guanidine monohydrochloride also appears in cosmetics, pharmaceutical, cannabis databases.