What is the NOAEL for 17beta-Estradiol?
17beta-Estradiol has 100 NOAEL studies in the database. The lowest reported value is 0.00005 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
Prop 65
REACH Registered
Cosmetic Ingredient
17beta-Estradiol
Also known as: Estradiol, Oestradiol, Dihydrofolliculin, beta-Estradiol, Estra-1,3,5(10)-triene-3,17-diol (+15 more)
CAS 50-28-2
17beta-Estradiol (CAS 50-28-2) is a chemical substance; key hazard signal: cancer. Key regulatory status: California Proposition 65, REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, CA Prop 65.
Cross-Vertical Regulatory Divergence
17beta-Estradiol is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H351, H360, H360FD, H362, H372, H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
13
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
17beta-Estradiol
CAS Number
50-28-2
DTXSID
DTXSID0020573
Molecular Formula
C18H24O2
InChI Key
VOXZDWNPVJITMN-ZBRFXRBCSA-N
Monoisotopic Mass
272.17763
Synonyms
EstradiolOestradiolDihydrofolliculinbeta-EstradiolEstra-1,3,5(10)-triene-3,17-diol3,17beta-Dihydroxyestra-1,3,5-triene3,17-beta-Dihydroxyestra-1,3,5(10)-triene3,17beta-Dihydroxyoestra-1,3,5-triene3,17-beta-Dihydroxyoestra-1,3,5-triene3,17-beta-Dihydroxy-1,3,5(10)-oestratrieneDihydroxyoestrinEINECS 200-023-8
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
13 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| detected; MN Chemical Screening; wastewater | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.00236103486856901 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 0.0391052348934549 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 0.009 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.86 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2.9 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 8.378 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 17.9 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 19.5 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 20 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 28.84 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 30 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| <40 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 50 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 50.12 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 59 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 60 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 60.26 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 64.57 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 70 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 73 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 100 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 125 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 158.5 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 160 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 188.7 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 208.9 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 238 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 240 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 300 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 346.7 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 405 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 418 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| >500 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 627 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 631 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 741.3 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1010 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1023 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1259 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1290 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1580 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2920 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 3162 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 3162.28 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 3200 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 37000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 41900 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.00122754796036357 | uM | ACC | - | - | NTP_ICE_endocrine |
| 0.0126850623398566 | uM | ACC | - | - | NTP_ICE_endocrine |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Estradiol | 200-023-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ESTRADIOL
ChEMBL Phase
4
Adverse Events
3453
Bioactivity
32
Frequently Asked Questions
What regulatory lists include 17beta-Estradiol?
17beta-Estradiol appears on 8 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), pharmaceutical, detected; drinking_water; MN Chemical Screening, and 5 more. Source: EPA CPDat.
Is 17beta-Estradiol on the California Proposition 65 list?
Yes, 17beta-Estradiol is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is 17beta-Estradiol used in cosmetics?
Yes, 17beta-Estradiol is also indexed as a cosmetic ingredient under the name Estradiol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 17beta-Estradiol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 17beta-Estradiol have different safety status in cosmetics vs industrial chemicals?
17beta-Estradiol is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H351, H360, H360FD, H362, H372, H400, H410).
Is 17beta-Estradiol used outside industrial chemicals?
17beta-Estradiol also appears in cosmetics, pharmaceutical databases.