Is Estradiol safe in cosmetics?
Estradiol has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
POOR
Cosmetic Ingredient
Estradiol
Also known as: Oestradiol, Dihydrofolliculin, beta-Estradiol, Estra-1,3,5(10)-triene-3,17-diol, 3,17beta-Dihydroxyestra-1,3,5-triene (+14 more)
INCI: ESTRADIOL
Estradiol (CAS 50-28-2) is a cosmetic cosmetic ingredient functioning as Skin Conditioning (estrogenic hormone). NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Estradiol is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H351, H360, H360FD, H362, H372, H400, H410).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Skin Conditioning (estrogenic hormone)
Editorial assessment
POOR
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Restricted – FDA historically permitted hormones (estrogen, progesterone) in cosmetics at very low concentrations, but recent FDA guidance discourages this; effectively treated as drug ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Estradiol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Estradiol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Japan (Restricted): max N/A (IU limit)
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | banned | - | - |
| CA | banned | - | - |
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Roberts Skin Permeation (Mendeley 2022)
MW: 272.4
Log Kow: 4.01
Log Kp: -2.0123337350737254
Log Jmax: -9.75706122997042
Source: Roberts Cheruvu Mendeley 2022
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Editorial summary
Preliminary editorial summary for Estradiol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
prop65
Known Synonyms
Oestradiol
Dihydrofolliculin
beta-Estradiol
Estra-1,3,5(10)-triene-3,17-diol
3,17beta-Dihydroxyestra-1,3,5-triene
3,17-beta-Dihydroxyestra-1,3,5(10)-triene
3,17beta-Dihydroxyoestra-1,3,5-triene
3,17-beta-Dihydroxyoestra-1,3,5-triene
3,17-beta-Dihydroxy-1,3,5(10)-oestratriene
Dihydroxyoestrin
EINECS 200-023-8
3,17-Epidihydroxyoestratriene
D-3,17-beta-Estradiol
D-3,17beta-Estradiol
3,17-beta-Estradiol
Estradiol-3,17beta
1,3,5-Estratriene-3,17-beta-diol
Estra-1,3,5(10)-triene-3,17-beta-diol
17-beta-Estra-1,3,5(10)-triene-3,17-diol
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
Canada; pharmaceutical
Canada; pharmaceutical
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
detected; MN Chemical Screening; wastewater
detected; MN Chemical Screening; surface_water
detected; MN Chemical Screening; surface_water
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ESTRADIOL
ChEMBL ID
CHEMBL135
Max Phase
4
Adverse Event Associations
3453
Frequently Asked Questions
Is Estradiol allowed in the EU?
Estradiol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Estradiol do in cosmetics?
Estradiol functions as: Skin Conditioning (estrogenic hormone). It is classified as a cosmetic ingredient in our database. CAS number: 50-28-2.
Is Estradiol used outside cosmetics?
Estradiol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Estradiol have different safety status in cosmetics vs industrial chemicals?
Estradiol is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H351, H360, H360FD, H362, H372, H400, H410).
Compliance Tools
Check Estradiol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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