Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Estradiol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOEL | 0.4 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >300 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
CRITICAL: CMR substance (carcinogenic, mutagenic, reprotoxic); endocrine disruptor; prohibited in EU; reproductive toxicity; breast cancer risk. Do NOT formulate into cosmetics for any market targeting EU
Regulatory Flags
Frequently Asked Questions
Is Estradiol safe in cosmetics?
CRITICAL: CMR substance (carcinogenic, mutagenic, reprotoxic); endocrine disruptor; prohibited in EU; reproductive toxicity; breast cancer risk. Do NOT formulate into cosmetics for any market targeting EU The EU classifies Estradiol as "prohibited". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.
Is Estradiol allowed in the EU?
Estradiol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Estradiol do in cosmetics?
Estradiol functions as: Skin Conditioning (estrogenic hormone). It is classified as a cosmetic ingredient in our database. CAS number: 50-28-2.
What is the Margin of Safety for Estradiol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Estradiol?
The NOAEL (No Observed Adverse Effect Level) for Estradiol is 0.4 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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