Is Estradiol safe in cosmetics?
Estradiol has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Poor
Cosmetic Ingredient
Estradiol
Also known as: Oestradiol, Dihydrofolliculin, beta-Estradiol, Estra-1,3,5(10)-triene-3,17-diol, 3,17beta-Dihydroxyestra-1,3,5-triene (+14 more)
INCI: ESTRADIOL
Estradiol (CAS 50-28-2) is a cosmetic cosmetic ingredient functioning as Skin Conditioning (estrogenic hormone). NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 50-28-2 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning (estrogenic hormone)
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Restricted – FDA historically permitted hormones (estrogen, progesterone) in cosmetics at very low concentrations, but recent FDA guidance discourages this; effectively treated as drug ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Estradiol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Estradiol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Japan (Restricted): max N/A (IU limit)
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | banned | - | - |
| CA | banned | - | - |
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Roberts Skin Permeation (Mendeley 2022)
MW: 272.4
Log Kow: 4.01
Log Kp: -2.0123337350737254
Log Jmax: -9.75706122997042
Source: Roberts_Cheruvu_Mendeley_2022
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for Estradiol.
Regulatory Flags
prop65
Known Synonyms
Oestradiol
Dihydrofolliculin
beta-Estradiol
Estra-1,3,5(10)-triene-3,17-diol
3,17beta-Dihydroxyestra-1,3,5-triene
3,17-beta-Dihydroxyestra-1,3,5(10)-triene
3,17beta-Dihydroxyoestra-1,3,5-triene
3,17-beta-Dihydroxyoestra-1,3,5-triene
3,17-beta-Dihydroxy-1,3,5(10)-oestratriene
Dihydroxyoestrin
EINECS 200-023-8
3,17-Epidihydroxyoestratriene
D-3,17-beta-Estradiol
D-3,17beta-Estradiol
3,17-beta-Estradiol
Estradiol-3,17beta
1,3,5-Estratriene-3,17-beta-diol
Estra-1,3,5(10)-triene-3,17-beta-diol
17-beta-Estra-1,3,5(10)-triene-3,17-diol
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
Canada; pharmaceutical
Canada; pharmaceutical
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
detected; MN Chemical Screening; wastewater
detected; MN Chemical Screening; surface_water
detected; MN Chemical Screening; surface_water
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
Frequently Asked Questions
Is Estradiol allowed in the EU?
Estradiol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Estradiol do in cosmetics?
Estradiol functions as: Skin Conditioning (estrogenic hormone). It is classified as a cosmetic ingredient in our database. CAS number: 50-28-2.
Compliance Tools
Check Estradiol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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