What is the NOAEL for Nordihydroguaiaretic acid?
Nordihydroguaiaretic acid has 17 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
NOAEL Data
Cosmetic Ingredient
Nordihydroguaiaretic acid
Also known as: 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol, Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-, 2,3-Dimethyl-1,4-bis(3,4-dihydroxyphenyl)butane, 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(1,2-benzenediol) (+10 more)
CAS 500-38-9
Nordihydroguaiaretic acid (CAS 500-38-9) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for Nordihydroguaiaretic Acid →
SOURCE
noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Nordihydroguaiaretic acid
CAS Number
500-38-9
DTXSID
DTXSID5022437
Molecular Formula
C18H22O4
InChI Key
HCZKYJDFEPMADG-UHFFFAOYSA-N
Monoisotopic Mass
302.151809
Synonyms
1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-4,4'-(2,3-Dimethyltetramethylene)dipyrocatecholPyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-2,3-Dimethyl-1,4-bis(3,4-dihydroxyphenyl)butane4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(1,2-benzenediol)EINECS 207-903-0Nordihydroguairaretic acidNSC 682984Norguaiaretic acid, dihydro2,3-bis(3,4-dihydroxyphenylmethyl)butaneNDGANSC 4291
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Antioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5.90481698643894 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 34.02950699 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 2.999890754764 | uM | ACC | - | - | NTP_ICE_endocrine |
| 33.32580045 | uM | ACC | - | - | NTP_ICE_endocrine |
| 93.1 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| 270 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 7BO8G1BYQU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7BO8G1BYQU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7BO8G1BYQU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7BO8G1BYQU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7.14e-8 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 0.1285 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0158 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0998 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.218 | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 17 of 17 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: NO ADI ALLOCATED mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Nordihydroguaiaretic acid?
Nordihydroguaiaretic acid appears on 2 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Nordihydroguaiaretic acid used in cosmetics?
Yes, Nordihydroguaiaretic acid is also indexed as a cosmetic ingredient under the name Nordihydroguaiaretic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Nordihydroguaiaretic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Nordihydroguaiaretic acid used outside industrial chemicals?
Nordihydroguaiaretic acid also appears in cosmetics, food safety databases.