What is the NOAEL for Resveratrol?
Resveratrol has 13 NOAEL studies in the database. The lowest reported value is 5.860e-8 fraction in Human. Source: NTP ICE adme parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Resveratrol
Also known as: 1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-, NSC 327430, 3,4',5-Trihydroxystilbene, 3,5,4'-Trihydroxystilbene, 5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediol (+3 more)
CAS 501-36-0
Resveratrol (CAS 501-36-0) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Resveratrol is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
13
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Resveratrol
CAS Number
501-36-0
Molecular Formula
C14H12O3
InChI Key
LUKBXSAWLPMMSZ-OWOJBTEDSA-N
Monoisotopic Mass
228.078644
Synonyms
1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-NSC 3274303,4',5-Trihydroxystilbene3,5,4'-Trihydroxystilbene5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediolUNII-Q369O8926LPrevention 8Resvida
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
AntioxidantHumectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.000032 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 6.800e+4 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 8.000e+4 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| =344 | mg/kg bw/day | BMDL (05) | oral | Rat | EFSA |
| 62.9 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| Q369O8926L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5.860e-8 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 5000 | nM | LEL | - | - | NTP ICE endocrine |
| 1.000e+4 | nM | LEL | - | - | NTP ICE endocrine |
| 5.000e+4 | nM | LEL | - | - | NTP ICE endocrine |
| 1.000e+5 | nM | LEL | - | - | NTP ICE endocrine |
| 0.0058 | unitless | RBA | - | - | NTP ICE endocrine |
| 0.0065 | unitless | RBA | - | - | NTP ICE endocrine |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol | 610-504-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
RESVERATROL
ChEMBL Phase
3
Adverse Events
0
Bioactivity
12
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
2 records
FDA GRAS: At the notifier's request, FDA ceased to evaluate this notice
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Resveratrol?
Resveratrol appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Resveratrol used in cosmetics?
Yes, Resveratrol is also indexed as a cosmetic ingredient under the name Resveratrol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Resveratrol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Resveratrol have different safety status in cosmetics vs industrial chemicals?
Resveratrol is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is Resveratrol used outside industrial chemicals?
Resveratrol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.