EXCELLENT Antioxidant Dermal Penetration

Resveratrol

Also known as: 1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-, NSC 327430, 3,4',5-Trihydroxystilbene, 3,5,4'-Trihydroxystilbene, 5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediol (+3 more)

INCI: RESVERATROL

Resveratrol (CAS 501-36-0) is a cosmetic antioxidant functioning as Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.

View industrial chemical safety profile for CAS 501-36-0 →

CAS Number
501-36-0
View industrial chemical safety profile →
Function
Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution active; SIRT1 activator; stilbene polyphenol
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.

Chemistry & Identifiers

EC Number
610-504-8
ChEBI: CHEBI:27881 UNII: Q369O8926L Wikidata: Q407329

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes Permitted in cosmetics; no FDA restrictions; limited CIR assessment published; extensively studied in peer-reviewed literature; used at 0.1–1% in anti-aging and anti-pollution serums

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Resveratrol.

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Resveratrol, relevant to systemic exposure and MoS calculations.

Absorption %
12-20%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
228.2 Da
Log P
3.1
Systemic Absorption
yes
Topical Bioavailability
8-16%
Safety Margin Factor
moderate
Vehicle Dependent
Yes — absorption varies by formulation

Source: Arch Dermatol Res 2013

Endocrine Disruptor Evidence (Expanded)

Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.

Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα, ERβ, AhR
LOEC: 100 nM
EU status: allowed

mixed agonist/antagonist (ER context-dependent)

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

Additional Jurisdictional Restrictions (1)
Jurisdiction Status Max % Product Type
CN restricted 1 Skin care products

Typical Use Concentrations

Reported concentration ranges per product category from SCCS/CIR/industry sources.

Product Category Typical Range Max Reported Source
Serum 0.1–1 2 CIR Safety Assessment

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Antioxidant Humectant

Editorial summary

Preliminary editorial summary for Resveratrol — not a computed safety verdict. See the sourced toxicological data above.

Regulatory Flags

anti-pollution ahr-antagonist nrf2-activator sirt1-activator pah-blocker anti-inflammatory light-sensitive encapsulation-recommended stilbene-polyphenol anti-aging

Known Synonyms

1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)- NSC 327430 3,4',5-Trihydroxystilbene 3,5,4'-Trihydroxystilbene 5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediol UNII-Q369O8926L Prevention 8 Resvida

Chemical Function

Antioxidant Humectant

Regulatory Lists

Canada; pharmaceutical

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical and food safety data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound
RESVERATROL
ChEMBL ID
CHEMBL165
Max Phase
3
View full pharmaceutical profile →
SOURCE EFSA / FDA GRAS food_additives + fda_gras_enriched

Food Safety Data

Same-CAS food additive or FDA GRAS records from the core public database.

Food Name
Resveratrol
FDA GRAS
At the notifier's request, FDA ceased to evaluate this notice
GRN
224
Food Category
preservative

Ingredient in bottled water products at levels up to 10 milligrams per liter

View full food safety profile →

Frequently Asked Questions

Is Resveratrol safe in cosmetics?

Resveratrol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.

Is Resveratrol allowed in the EU?

Resveratrol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Resveratrol do in cosmetics?

Resveratrol functions as: Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution active; SIRT1 activator; stilbene polyphenol. It is classified as a Antioxidant in our database. CAS number: 501-36-0.

Is Resveratrol used outside cosmetics?

Resveratrol also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Resveratrol have different safety status in cosmetics vs industrial chemicals?

Resveratrol is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.

Compliance Tools

Check Resveratrol compliance across multiple jurisdictions:

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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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