Excellent Antioxidant Dermal Penetration

Resveratrol

INCI: RESVERATROL

CAS Number
501-36-0
Function
Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution active; SIRT1 activator; stilbene polyphenol
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted in cosmetics; no FDA restrictions; limited CIR assessment published; extensively studied in peer-reviewed literature; used at 0.1–1% in anti-aging and anti-pollution serums

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Resveratrol, relevant to systemic exposure and MoS calculations.

Absorption %
12-20%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
228.2 Da
Log P
3.1
Systemic Absorption
yes
Topical Bioavailability
8-16%
Safety Margin Factor
moderate
Vehicle Dependent
Yes — absorption varies by formulation

Source: Arch Dermatol Res 2013

Expert Verdict

Resveratrol is a mechanistically validated anti-pollution active that antagonizes PAH-mediated AhR transcriptional activation while activating Nrf2 for cytoprotection and SIRT1 for anti-aging benefits; trans-resveratrol requires encapsulation or stabilized delivery systems due to light and oxygen sensitivity.

⚠️
Concern Level: None

Regulatory Flags

anti-pollution ahr-antagonist nrf2-activator sirt1-activator pah-blocker anti-inflammatory light-sensitive encapsulation-recommended stilbene-polyphenol anti-aging

Frequently Asked Questions

Is Resveratrol safe in cosmetics?

Resveratrol is a mechanistically validated anti-pollution active that antagonizes PAH-mediated AhR transcriptional activation while activating Nrf2 for cytoprotection and SIRT1 for anti-aging benefits; trans-resveratrol requires encapsulation or stabilized delivery systems due to light and oxygen sensitivity. The EU classifies Resveratrol as "permitted". Safety rating: EXCELLENT.

Is Resveratrol allowed in the EU?

Resveratrol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Resveratrol do in cosmetics?

Resveratrol functions as: Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution active; SIRT1 activator; stilbene polyphenol. It is classified as a Antioxidant in our database. CAS number: 501-36-0.

What is the Margin of Safety for Resveratrol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Resveratrol compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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