Is Resveratrol safe in cosmetics?
Resveratrol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Resveratrol
Also known as: 1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-, NSC 327430, 3,4',5-Trihydroxystilbene, 3,5,4'-Trihydroxystilbene, 5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediol (+3 more)
INCI: RESVERATROL
Resveratrol (CAS 501-36-0) is a cosmetic antioxidant functioning as Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 501-36-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Resveratrol is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution active; SIRT1 activator; stilbene polyphenol
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; no FDA restrictions; limited CIR assessment published; extensively studied in peer-reviewed literature; used at 0.1–1% in anti-aging and anti-pollution serums
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Resveratrol.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Resveratrol, relevant to systemic exposure and MoS calculations.
Absorption %
12-20%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
228.2 Da
Log P
3.1
Systemic Absorption
yes
Topical Bioavailability
8-16%
Safety Margin Factor
moderate
Vehicle Dependent
Yes — absorption varies by formulation
Source: Arch Dermatol Res 2013
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα, ERβ, AhR
LOEC: 100 nM
EU status: allowed
mixed agonist/antagonist (ER context-dependent)
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | restricted | 1 | Skin care products |
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Serum | 0.1–1 | 2 | CIR/Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "501-36-0", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_a…
anti_aging
{"anti_aging_claim": "antioxidant-protection, anti-wrinkle, firming, brightening", "mechanism_of_action": "SIRT1 activator, antioxidant, anti-inflammatory, protects from UV damage", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Yes", "wrinkle_reduction_pct": "10-20", "clinical_study_duration_weeks": "12", "sample_size": "38", "double_blind": "…
anti_pollution
{"cas_number": "501-36-0", "ingredient_class": "Nrf2_activator/AhR_antagonist/antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging/enzyme_induction", "pollution_types_targeted": "PM2_5/PM10/PAH/ozone/UV_A/cigarette_smoke", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "yes", "ozone_protection": "yes…
antioxidant
{"cas_number": "501-36-0", "antioxidant_class": "polyphenol", "chemical_subclass": "stilbene", "molecular_weight_daltons": "228.24", "orac_value_umol_te_per_g": "15185", "dpph_radical_scavenging_ic50_ug_per_ml": "12-22", "abts_trolox_equivalent": "1.15", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "yes", "hydroxyl_radical_scavenging": "high", "lipid_peroxidation_inhibition_…
baby_pediatric
{"cas_number": "501-36-0", "ingredient_class": "other", "pediatric_safety_rating": "acceptable", "minimum_age_months": "24", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Antioxidant, adult focus", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Approp…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,sensitive,combination,normal,acne-prone,mature", "acne_safe": "yes", "source": "Antioxidant"}
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "0.5", "typical_concentration_pct": "0.3", "product_type": "Moisturizer", "function_at_concentration": "Antioxidant", "source": "Clinical literature"}
dermal_absorption
{"molecular_weight_da": "228.2", "log_p_value": "3.1", "skin_penetration_level": "epidermis", "penetration_depth": "epidermis/dermis", "absorption_pct": "12-20", "systemic_absorption": "yes", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "8-16", "safety_margin_factor": "moderate", "source": "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Resveratrol.
Regulatory Flags
anti-pollution
ahr-antagonist
nrf2-activator
sirt1-activator
pah-blocker
anti-inflammatory
light-sensitive
encapsulation-recommended
stilbene-polyphenol
anti-aging
Known Synonyms
1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-
NSC 327430
3,4',5-Trihydroxystilbene
3,5,4'-Trihydroxystilbene
5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediol
UNII-Q369O8926L
Prevention 8
Resvida
Chemical Function
Antioxidant
Humectant
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
RESVERATROL
ChEMBL ID
CHEMBL165
Max Phase
3
Frequently Asked Questions
Is Resveratrol allowed in the EU?
Resveratrol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Resveratrol do in cosmetics?
Resveratrol functions as: Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution active; SIRT1 activator; stilbene polyphenol. It is classified as a Antioxidant in our database. CAS number: 501-36-0.
Is Resveratrol used outside cosmetics?
Resveratrol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Resveratrol have different safety status in cosmetics vs industrial chemicals?
Resveratrol is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Resveratrol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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