NOAEL Data REACH Registered Cosmetic Ingredient

1,3-Propanediol

Also known as: Bio-PDO, NSC 65426, BRN 0969155, EINECS 207-997-3, UNII-5965N8W85T (+10 more)

CAS 504-63-2

1,3-Propanediol (CAS 504-63-2) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Propanediol →

SOURCE noael studies public
NOAEL studies
46
SOURCE chemical inventory jurisdictions
Regulatory lists
3
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields
Name
1,3-Propanediol
CAS Number
504-63-2
DTXSID
DTXSID8041246
Molecular Formula
C3H8O2
InChI Key
YPFDHNVEDLHUCE-UHFFFAOYSA-N
Monoisotopic Mass
76.052429
Synonyms
Bio-PDONSC 65426BRN 0969155EINECS 207-997-3UNII-5965N8W85T(HOCH2)2CH22-(hydroxymethyl)ethanolCH2(CH2OH)2HO(CH2)3OHHOCH2CH2CH2OHbeta-propylene glycolomega-propanediol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records
FragranceChemical reaction regulatorSolventStabilizing agentHumectant

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
SCIL (9/2019)USEPASafer Chemical Ingredients List
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 46 of 46 studies
ValueUnitEndpointRouteSpeciesSource
=12mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
5965N8W85TUNIIFDA UNII substance identifier--openFDA substances
5965N8W85TUNIIFDA UNII substance identifier--openFDA substances
5965N8W85TUNIIFDA UNII substance identifier--openFDA substances
5965N8W85TUNIIFDA UNII substance identifier--openFDA substances
=15000mg/kg bwLD50oralRatNTP_ICE_acute_oral
=15mg/kg/dayNOAELoralratCIR_vision_codex
=15mg/kg/dayNOAELoralratCIR_vision_codex
=15mg/kg/dayNOAELoralratCIR_vision_codex
=15mg/kg/dayNOAELoralratCIR_vision_codex
=23mg/kg/dayNOAELinhalationratCIR_vision_codex
=23mg/kg/dayNOAELinhalationratCIR_vision_codex
=23mg/kg/dayNOAELinhalationratCIR_vision_codex
=23mg/kg/dayNOAELinhalationratCIR_vision_codex
=50mg/kg/dayNOAELoralratCIR_vision_codex
=50mg/kg/dayNOAELoralratCIR_vision_codex
=50mg/kg/dayNOAELoralratCIR_vision_codex
=50mg/kg/dayNOAELoralratCIR_vision_codex
=100mg/kg/dayNOAELoralratCIR_vision_codex
=100mg/kg/dayNOAELoralratCIR_vision_codex
=100mg/kg/dayNOAELoralratCIR_vision_codex
=100mg/kg/dayNOAELoralratCIR_vision_codex
=150mg/kg/dayNOAELoralratCIR_vision_codex
=150mg/kg/dayNOAELoralratCIR_vision_codex
=150mg/kg/dayNOAELoralratCIR_vision_codex
=150mg/kg/dayNOAELoralratCIR_vision_codex
=200mg/kg/dayNOAELoral-CIR_vision_codex
=200mg/kg/dayNOAELoral-CIR_vision_codex
=200mg/kg/dayNOAELoral-CIR_vision_codex
=200mg/kg/dayNOAELoral-CIR_vision_codex
=400mg/kg/dayNOAELoralratCIR_vision_codex
=400mg/kg/dayNOAELoralratCIR_vision_codex
=400mg/kg/dayNOAELoralratCIR_vision_codex
=400mg/kg/dayNOAELoralratCIR_vision_codex
=500mg/kg/dayNOAELoralratCIR_vision_codex
=500mg/kg/dayNOAELoralratCIR_vision_codex
=500mg/kg/dayNOAELoralratCIR_vision_codex
=500mg/kg/dayNOAELoralratCIR_vision_codex
=600mg/kg/dayNOAELoralratCIR_vision_codex
=600mg/kg/dayNOAELoralratCIR_vision_codex
=600mg/kg/dayNOAELoralratCIR_vision_codex
=600mg/kg/dayNOAELoralratCIR_vision_codex
=1000mg/kg/dayNOAELoralratCIR_vision_codex
=1000mg/kg/dayNOAELoralratCIR_vision_codex
=1000mg/kg/dayNOAELoralratCIR_vision_codex
=1000mg/kg/dayNOAELoralratCIR_vision_codex

Showing 46 of 46 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredPropane-1,3-diol207-997-3ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
humectant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL 1,3-PROPANEDIOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

FDA GRAS: FDA has no questions

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 1,3-Propanediol?

1,3-Propanediol has 46 NOAEL studies in the database. The lowest reported value is 12 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 1,3-Propanediol?

1,3-Propanediol appears on 3 regulatory/inventory lists including IFRA Transparency, SCIL (9/2019), Canada; pharmaceutical. Source: EPA CPDat.

Is 1,3-Propanediol used in cosmetics?

Yes, 1,3-Propanediol is also indexed as a cosmetic ingredient under the name Propanediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,3-Propanediol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,3-Propanediol used outside industrial chemicals?

1,3-Propanediol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.