NOAEL Data REACH Registered Cosmetic Ingredient

1,3-Propanediol

Also known as: Bio-PDO, NSC 65426, BRN 0969155, EINECS 207-997-3, UNII-5965N8W85T (+10 more)

CAS 504-63-2

1,3-Propanediol (CAS 504-63-2) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Propanediol →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields

Name

1,3-Propanediol

CAS Number

504-63-2

Molecular Formula

C3H8O2

InChI Key

YPFDHNVEDLHUCE-UHFFFAOYSA-N

Monoisotopic Mass

76.052429

Synonyms

Bio-PDONSC 65426BRN 0969155EINECS 207-997-3UNII-5965N8W85T(HOCH2)2CH22-(hydroxymethyl)ethanolCH2(CH2OH)2HO(CH2)3OHHOCH2CH2CH2OHbeta-propylene glycolomega-propanediol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records

FragranceChemical reaction regulatorSolventStabilizing agentHumectant

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
Canada; pharmaceutical	DrugBank	DrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 13 of 13 studies

Value	Unit	Endpoint	Route	Species	Source
=12	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
5965N8W85T	UNII	FDA UNII substance identifier	-	-	openFDA substances
=1.500e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=15	mg/kg/day	NOAEL	oral	rat	CIR Safety Assessment
=23	mg/kg/day	NOAEL	inhalation	rat	CIR Safety Assessment
=50	mg/kg/day	NOAEL	oral	rat	CIR Safety Assessment
=100	mg/kg/day	NOAEL	oral	rat	CIR Safety Assessment
=150	mg/kg/day	NOAEL	oral	rat	CIR Safety Assessment
=200	mg/kg/day	NOAEL	oral	-	CIR Safety Assessment
=400	mg/kg/day	NOAEL	oral	rat	CIR Safety Assessment
=500	mg/kg/day	NOAEL	oral	rat	CIR Safety Assessment
=600	mg/kg/day	NOAEL	oral	rat	CIR Safety Assessment
=1000	mg/kg/day	NOAEL	oral	rat	CIR Safety Assessment

Showing 13 of 13 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Propane-1,3-diol	207-997-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed 1,3-PROPANEDIOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

FDA GRAS: FDA has no questions

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 1,3-Propanediol?

1,3-Propanediol has 13 NOAEL studies in the database. The lowest reported value is 12 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.

What regulatory lists include 1,3-Propanediol?

1,3-Propanediol appears on 3 regulatory/inventory lists including IFRA Transparency, SCIL (9/2019), Canada; pharmaceutical. Source: EPA CPDat.

Is 1,3-Propanediol used in cosmetics?

Yes, 1,3-Propanediol is also indexed as a cosmetic ingredient under the name Propanediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,3-Propanediol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,3-Propanediol used outside industrial chemicals?

1,3-Propanediol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.