Also known as: Bio-PDO, NSC 65426, BRN 0969155, EINECS 207-997-3, UNII-5965N8W85T (+10 more)
INCI: PROPANEDIOL
Propanediol (CAS 504-63-2) is a cosmetic humectant functioning as Humectant; solvent; antimicrobial contributor; water activity reduction agent;. Reported NOAEL =15 mg/kg/day in rat (CIR Safety Assessment); EU Regulation 1223/2009 status: permitted; 5 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
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Margin of Safety, dermal absorption, and sensitization profile summaries for Propanediol.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Propanediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =15 mg/kg/day | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =15 mg/kg/day | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =15 mg/kg/day | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =15 mg/kg/day | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =23 mg/kg/day | inhalation | rat | inhalation toxicity | CIR Safety Assessment |
| NOAEL | =23 mg/kg/day | inhalation | rat | inhalation toxicity | CIR Safety Assessment |
| NOAEL | =23 mg/kg/day | inhalation | rat | inhalation toxicity | CIR Safety Assessment |
| NOAEL | =23 mg/kg/day | inhalation | rat | inhalation toxicity | CIR Safety Assessment |
| NOAEL | =50 mg/kg/day | oral | rat | oral toxicity | CIR Safety Assessment |
| NOAEL | =50 mg/kg/day | oral | rat | oral toxicity | CIR Safety Assessment |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
ngredients, and concluded that seven alkane diols are safe in cosmetics in the present practices of use and concentration described in this safety assessment, but that the available data are insufficient to make a determination of safety for three ingredients, namely 1,4-Butanediol, 2,3-Bu- taned
ngredients, and concluded that seven alkane diols are safe in cosmetics in the present practices of use and concentration described in this safety assessment, but that the available data are insufficient to make a determination of safety for three ingredients, namely 1,4-Butanediol, 2,3-Bu- taned
ngredients, and concluded that seven alkane diols are safe in cosmetics in the present practices of use and concentration described in this safety assessment, but that the available data are insufficient to make a determination of safety for three ingredients, namely 1,4-Butanediol, 2,3-Bu- taned
ngredients, and concluded that seven alkane diols are safe in cosmetics in the present practices of use and concentration described in this safety assessment, but that the available data are insufficient to make a determination of safety for three ingredients, namely 1,4-Butanediol, 2,3-Bu- taned
ngredients, and concluded that seven alkane diols are safe in cosmetics in the present practices of use and concentration described in this safety assessment, but that the available data are insufficient to make a determination of safety for three ingredients, namely 1,4-Butanediol, 2,3-Bu- taned
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Preliminary editorial summary for Propanediol — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Propanediol by CAS number or substance name.
Same-CAS public records found in food safety data.
Same-CAS food additive or FDA GRAS records from the core public database.
To be used in place of 1,2-propanediol (as specified in 21 CFR 184.1666(c)) at levels not to exceed current good manufacturing practice; maximum levels of 5 percent for alcoholic beverages, 24 percent for confections and frostings, 2.5 percent for frozen...
View full food safety profile →Propanediol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Propanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Propanediol functions as: Humectant; solvent; antimicrobial contributor; water activity reduction agent; self-preservation contributor. It is classified as a Humectant in our database. CAS number: 504-63-2.
The NOAEL (No Observed Adverse Effect Level) for Propanediol is =15 mg/kg/day based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR Safety Assessment.
Propanediol also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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