Also known as: 1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-, 2-(2-butoxietoxi)etil 6-propilpiperonil eter, 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether, 2-(2-Butoxyethoxy)ethyl-6-propylpiperonylether, 3, 4-Methylenedioxy-6-propylbenzyl butyl diethyleneglycol ether (+15 more)
CAS 51-03-6
Piperonyl butoxide (CAS 51-03-6) is a chemical substance with GHS signal word Warning; key hazard signal: H335; H319; H400; H410. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, ILO ICSC, EPA TRI.
Piperonyl butoxide is prohibited in EU cosmetics but has active industrial GHS classifications (H335, H319, H400, H410).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 30, Sup 7 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| STOT SE 3; Eye Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1 | H335; H319; H400; H410 | GHS07; GHS09 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| baby_food; detected; Pesticides; residue | FDA | United States Food and Drug Administration (FDA) |
| Pesticides; residue | FDA | United States Food and Drug Administration (FDA) |
| detected; general_crops; Pesticides; residue | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 23.66 | uM | AC50 | - | - | NTP ICE endocrine |
| 17.93 | uM | ACC | - | - | NTP ICE endocrine |
| 76.01 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| =3.875 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| =1.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 3 | unitless | EPA Classification | Inhalation | - | NTP ICE acute inhalation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 4 | unitless | EPA Classification | Inhalation | - | NTP ICE acute inhalation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 2 | unitless | EPA classification | Dermal | Rabbit | NTP ICE skin irritation |
| 3 | unitless | EPA classification | Dermal | Rat | NTP ICE acute dermal |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP ICE acute oral |
| =3 | Unitless | EPA classification | oral | Rat | NTP ICE acute oral |
| =3 | Unitless | EPA classification | oral | Rat (Male/Female) | NTP ICE acute oral |
| 3 | unitless | EPA classification | Dermal | Rabbit | NTP ICE skin irritation |
| 4 | unitless | EPA classification | Dermal | Rat | NTP ICE acute dermal |
| =4 | Unitless | EPA classification | oral | Rat (Male/Female) | NTP ICE acute oral |
| =4 | Unitless | EPA classification | oral | Rat (Female) | NTP ICE acute oral |
| 4 | unitless | EPA classification | Dermal | Rabbit | NTP ICE skin irritation |
| LWK91TU9AH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 1 | unitless | GHS Classification | Dermal | Guinea pig | NTP ICE skin sensitization |
| =4 | Unitless | GHS classification | oral | Rat | NTP ICE acute oral |
| =4 | Unitless | GHS classification | oral | Rat (Female) | NTP ICE acute oral |
| 5 | unitless | GHS classification | Dermal | Rat | NTP ICE acute dermal |
| =5 | Unitless | GHS classification | oral | Rat (Female) | NTP ICE acute oral |
| =5 | Unitless | GHS classification | oral | Rat (Male/Female) | NTP ICE acute oral |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP ICE cancer |
| >2.05 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >2.06 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >2.07 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >2.09 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >2.21 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >2.99 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >5.2 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >5.9 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =1750 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1750 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| >2000 | mg/kg | LD50 | Dermal | Rat | NTP ICE acute dermal |
| >2000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| >2000 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =4570 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| >5000 | mg/kg | LD50 | Dermal | Rat | NTP ICE acute dermal |
| >5000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| >5000 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| =5630 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =6150 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =7220 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
Showing 50 of 86 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether | 200-076-7 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Piperonyl butoxide | - | - |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Piperonyl butoxide (CAS 51-03-6) is classified under EU CLP Annex VI as STOT SE 3; Eye Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H335; H319; H400; H410. Source: EU CLP Annex VI (ECHA).
Piperonyl butoxide has 86 NOAEL studies in the database. The lowest reported value is 0 fraction in Human. Source: NTP ICE adme parameters.
Piperonyl butoxide appears on 11 regulatory/inventory lists including active_ingredient; Europe; Pesticides, active_ingredient; agricultural; Pesticides, active_ingredient; agricultural; applied; Pesticides, and 8 more. Source: EPA CPDat.
Piperonyl butoxide is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Piperonyl butoxide is also indexed as a cosmetic ingredient under the name Piperonyl Butoxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Piperonyl butoxide is prohibited in EU cosmetics but has active industrial GHS classifications (H335, H319, H400, H410).
Piperonyl butoxide also appears in cosmetics, pharmaceutical databases.