Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Piperonyl Butoxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 ppm | oral | dog | Subchronic | COSMOS_DB |
| LOAEL | 600 ppm | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
| LOAEL | 10 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Primary use is pesticide synergist with eye irritant and organ toxicity hazards; not approved for cosmetic formulation.
Regulatory Flags
Frequently Asked Questions
Is Piperonyl Butoxide safe in cosmetics?
Primary use is pesticide synergist with eye irritant and organ toxicity hazards; not approved for cosmetic formulation. The EU classifies Piperonyl Butoxide as "prohibited". Safety rating: POOR. 4 toxicological study endpoint(s) are available in our database.
Is Piperonyl Butoxide allowed in the EU?
Piperonyl Butoxide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperonyl Butoxide do in cosmetics?
Piperonyl Butoxide functions as: Synergist (pesticide use) — not a standard cosmetic function. It is classified as a cosmetic ingredient in our database. CAS number: 51-03-6.
What is the Margin of Safety for Piperonyl Butoxide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Piperonyl Butoxide?
The NOAEL (No Observed Adverse Effect Level) for Piperonyl Butoxide is 100 ppm based on a Subchronic study via oral route in dog. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Piperonyl Butoxide compliance across multiple jurisdictions:
Related Ingredients
Is Piperonyl Butoxide in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Piperonyl Butoxide in your formulation.