What is the NOAEL for Diosgenin?
Diosgenin has 5 NOAEL studies in the database. The lowest reported value is K49P2K8WLX UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diosgenin
Also known as: Spirost-5-en-3-ol, (3β,25R)-, Spirost-5-en-3β-ol, (25R)-, (3β,25R)-Spirost-5-en-3-ol, (25R)-Spirost-5-en-3β-ol, 25α-Spirost-5-en-3β-ol (+3 more)
CAS 512-04-9
Diosgenin (CAS 512-04-9) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Diosgenin
CAS Number
512-04-9
DTXSID
DTXSID00895074
Molecular Formula
C27H42O3
InChI Key
WQLVFSAGQJTQCK-VKROHFNGSA-N
Monoisotopic Mass
414.313395
Synonyms
Spirost-5-en-3-ol, (3β,25R)-Spirost-5-en-3β-ol, (25R)-(3β,25R)-Spirost-5-en-3-ol(25R)-Spirost-5-en-3β-ol25α-Spirost-5-en-3β-olSpiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-[2H]pyran], spirost-5-en-3-ol deriv.NitogeninNSC 33396
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| K49P2K8WLX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K49P2K8WLX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K49P2K8WLX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K49P2K8WLX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >8000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (20R,25R)-spirost-5-en-3β-ol | 208-134-3 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DISOGENIN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
6
Frequently Asked Questions
Is Diosgenin used in cosmetics?
Yes, Diosgenin is also indexed as a cosmetic ingredient under the name Diosgenin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diosgenin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diosgenin used outside industrial chemicals?
Diosgenin also appears in cosmetics, pharmaceutical databases.