Is Diosgenin safe in cosmetics?
Diosgenin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Diosgenin
Also known as: Spirost-5-en-3-ol, (3β,25R)-, Spirost-5-en-3β-ol, (25R)-, (3β,25R)-Spirost-5-en-3-ol, (25R)-Spirost-5-en-3β-ol, 25α-Spirost-5-en-3β-ol (+3 more)
INCI: DIOSGENIN
Diosgenin (CAS 512-04-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning (steroidal sapogenin from wild yam). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 512-04-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (steroidal sapogenin from wild yam)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-ol
InChIKey
WQLVFSAGQJTQCK-VKROHFNGSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not on FDA prohibited/restricted list
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diosgenin.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Diosgenin.
Known Synonyms
Spirost-5-en-3-ol, (3β,25R)-
Spirost-5-en-3β-ol, (25R)-
(3β,25R)-Spirost-5-en-3-ol
(25R)-Spirost-5-en-3β-ol
25α-Spirost-5-en-3β-ol
Spiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-[2H]pyran], spirost-5-en-3-ol deriv.
Nitogenin
NSC 33396
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DISOGENIN
ChEMBL ID
CHEMBL412437
Frequently Asked Questions
Is Diosgenin allowed in the EU?
Diosgenin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diosgenin do in cosmetics?
Diosgenin functions as: Skin conditioning (steroidal sapogenin from wild yam). It is classified as a cosmetic ingredient in our database. CAS number: 512-04-9.
Is Diosgenin used outside cosmetics?
Diosgenin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diosgenin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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DIOSCOREA JAPONICA FRUIT/CALCIUM HYDROXIDE/MAGNESIUM HYDROXIDE/POTASSIUM OXIDE/SILICA/SODIUM HYDROXIDE/SUCROSE FERMENT FILTRATE
Good
Browse nearby
Skin Conditioning, Skin Protecting
DIOXOLANE
Good
Browse nearby
Solvent
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