Diosgenin

INCI: DIOSGENIN

CAS Number
512-04-9
Function
Skin conditioning (steroidal sapogenin from wild yam)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not on FDA prohibited/restricted list

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Steroidal sapogenin with potential skin and eye irritation risk; may interact with estrogen/progesterone receptors at pharmacological concentrations; limited independent cosmetic toxicological data and no CIR monograph as standalone ingredient.

โš ๏ธ
Concern Level: Moderate

Frequently Asked Questions

Is Diosgenin safe in cosmetics?

Steroidal sapogenin with potential skin and eye irritation risk; may interact with estrogen/progesterone receptors at pharmacological concentrations; limited independent cosmetic toxicological data and no CIR monograph as standalone ingredient. The EU classifies Diosgenin as "permitted". Safety rating: MODERATE.

Is Diosgenin allowed in the EU?

Diosgenin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diosgenin do in cosmetics?

Diosgenin functions as: Skin conditioning (steroidal sapogenin from wild yam). It is classified as a cosmetic ingredient in our database. CAS number: 512-04-9.

What is the Margin of Safety for Diosgenin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Diosgenin in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Diosgenin in your formulation.