What is the NOAEL for 4-Nitro-1,3-benzenediamine?
4-Nitro-1,3-benzenediamine has 2 NOAEL studies in the database. The lowest reported value is 0D5U5EW62Z UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Nitro-1,3-benzenediamine
Also known as: 4-Nitro-m-phenylenediamine, 3-13-00-00099, BRN 2094904, 1,3-Diamino-4-nitrobenzene, 2,4-Diaminonitrobenzene (+5 more)
CAS 5131-58-8
4-Nitro-1,3-benzenediamine (CAS 5131-58-8) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for 4-Nitro-M-Phenylenediamine →
Cross-Vertical Regulatory Divergence
4-Nitro-1,3-benzenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H334).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
2
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
4-Nitro-1,3-benzenediamine
CAS Number
5131-58-8
Molecular Formula
C6H7N3O2
InChI Key
DPIZKMGPXNXSGL-UHFFFAOYSA-N
Monoisotopic Mass
153.053826
Synonyms
4-Nitro-m-phenylenediamine3-13-00-00099BRN 20949041,3-Diamino-4-nitrobenzene2,4-DiaminonitrobenzeneEINECS 225-876-34-Nitro-1,3-phenylenediamineNSC 95754-Nitro-1,3-fenylendiaminUNII-0D5U5EW62Z
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 2 of 2 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0D5U5EW62Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =4500 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 2 of 2 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-nitro-m-phenylenediamine | 225-876-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL1427182
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 4-Nitro-1,3-benzenediamine?
4-Nitro-1,3-benzenediamine appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is 4-Nitro-1,3-benzenediamine used in cosmetics?
Yes, 4-Nitro-1,3-benzenediamine is also indexed as a cosmetic ingredient under the name 4-Nitro-M-Phenylenediamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Nitro-1,3-benzenediamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-Nitro-1,3-benzenediamine have different safety status in cosmetics vs industrial chemicals?
4-Nitro-1,3-benzenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H334).
Is 4-Nitro-1,3-benzenediamine used outside industrial chemicals?
4-Nitro-1,3-benzenediamine also appears in cosmetics, pharmaceutical databases.