4-Nitro-M-Phenylenediamine

INCI: 4-NITRO-M-PHENYLENEDIAMINE

CAS Number
5131-58-8
Function
Hair dye (direct/semi-permanent)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Listed as a coal-tar hair dye under FDA; requires caution statement and patch test instructions per 21 CFR 740.2

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

EU-prohibited due to mutagenicity and genotoxicity concerns. Strong contact sensitizer. Do not formulate for EU market.

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Concern Level: High

Regulatory Flags

potential-allergen eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 4-Nitro-M-Phenylenediamine safe in cosmetics?

EU-prohibited due to mutagenicity and genotoxicity concerns. Strong contact sensitizer. Do not formulate for EU market. The EU classifies 4-Nitro-M-Phenylenediamine as "prohibited". Safety rating: POOR.

Is 4-Nitro-M-Phenylenediamine allowed in the EU?

4-Nitro-M-Phenylenediamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Nitro-M-Phenylenediamine do in cosmetics?

4-Nitro-M-Phenylenediamine functions as: Hair dye (direct/semi-permanent). It is classified as a cosmetic ingredient in our database. CAS number: 5131-58-8.

What is the Margin of Safety for 4-Nitro-M-Phenylenediamine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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