What is the NOAEL for S,S-(+)-Tetrandrine?
S,S-(+)-Tetrandrine has 4 NOAEL studies in the database. The lowest reported value is 29EX23D5AJ UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
S,S-(+)-Tetrandrine
Also known as: Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1β)-, (S,S)-Tetrandrine, 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-, Tetrandrine, (4aS,16aS)-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline (+10 more)
CAS 518-34-3
S,S-(+)-Tetrandrine (CAS 518-34-3) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
S,S-(+)-Tetrandrine is classified GHS Danger (H300, H302) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
S,S-(+)-Tetrandrine
CAS Number
518-34-3
DTXSID
DTXSID10178062
Molecular Formula
C38H42N2O6
InChI Key
WVTKBKWTSCPRNU-KYJUHHDHSA-N
Monoisotopic Mass
622.304287
Synonyms
Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1β)-(S,S)-Tetrandrine16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-Tetrandrine(4aS,16aS)-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline(+)-Tetrandrine16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, [4aS-(4aR*,16aR*)]-FanchinineHanfangchin ANSC 77037Sinomenine ATetrandrin
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 29EX23D5AJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 29EX23D5AJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 29EX23D5AJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 29EX23D5AJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
FANCHININ
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
7
Frequently Asked Questions
What regulatory lists include S,S-(+)-Tetrandrine?
S,S-(+)-Tetrandrine appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is S,S-(+)-Tetrandrine used in cosmetics?
Yes, S,S-(+)-Tetrandrine is also indexed as a cosmetic ingredient under the name Tetrandrine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for S,S-(+)-Tetrandrine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does S,S-(+)-Tetrandrine have different safety status in cosmetics vs industrial chemicals?
S,S-(+)-Tetrandrine is classified GHS Danger (H300, H302) in the chemicals database but is allowed in EU cosmetics.
Is S,S-(+)-Tetrandrine used outside industrial chemicals?
S,S-(+)-Tetrandrine also appears in cosmetics, pharmaceutical databases.