Tetrandrine

INCI: TETRANDRINE (BIS-BENZYLISOQUINOLINE ALKALOID)

CAS Number
518-34-3
Function
Skin conditioning agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Not specifically approved or banned for cosmetics. More commonly encountered in pharmaceutical research. FDA cosmetics database does not specifically restrict it

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Potent pharmacological alkaloid โ€” has documented anti-inflammatory, immunosuppressive, and anti-tumor activities. Hepatotoxicity reported at therapeutic doses. Primarily a pharmaceutical ingredient; cosmetic use is uncommon and data-sparse. If formulating, a comprehensive toxicological dossier would be required

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Concern Level: High

Frequently Asked Questions

Is Tetrandrine safe in cosmetics?

Potent pharmacological alkaloid โ€” has documented anti-inflammatory, immunosuppressive, and anti-tumor activities. Hepatotoxicity reported at therapeutic doses. Primarily a pharmaceutical ingredient; cosmetic use is uncommon and data-sparse. If formulating, a comprehensive toxicological dossier would be required The EU classifies Tetrandrine as "permitted". Safety rating: MODERATE.

Is Tetrandrine allowed in the EU?

Tetrandrine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetrandrine do in cosmetics?

Tetrandrine functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 518-34-3.

What is the Margin of Safety for Tetrandrine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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