Is Tetrandrine safe in cosmetics?
Tetrandrine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: prohibited.
Moderate
Cosmetic Ingredient
Tetrandrine
Also known as: Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1β)-, (S,S)-Tetrandrine, 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-, (4aS,16aS)-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, (+)-Tetrandrine (+9 more)
INCI: TETRANDRINE (BIS-BENZYLISOQUINOLINE ALKALOID)
Tetrandrine (CAS 518-34-3) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 518-34-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tetrandrine is classified GHS Danger (H300, H302) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene
InChIKey
WVTKBKWTSCPRNU-KYJUHHDHSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Not specifically approved or banned for cosmetics. More commonly encountered in pharmaceutical research. FDA cosmetics database does not specifically restrict it
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrandrine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Tetrandrine.
Known Synonyms
Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1β)-
(S,S)-Tetrandrine
16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-
(4aS,16aS)-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline
(+)-Tetrandrine
16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, [4aS-(4aR*,16aR*)]-
Fanchinine
Hanfangchin A
NSC 77037
Sinomenine A
Tetrandrin
d-Tetrandrine
(+)-Tetrandine
Tetrandine
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
FANCHININ
ChEMBL ID
CHEMBL176045
Frequently Asked Questions
Is Tetrandrine allowed in the EU?
Tetrandrine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrandrine do in cosmetics?
Tetrandrine functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 518-34-3.
Is Tetrandrine used outside cosmetics?
Tetrandrine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tetrandrine have different safety status in cosmetics vs industrial chemicals?
Tetrandrine is classified GHS Danger (H300, H302) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Tetrandrine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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