What is the GHS hazard classification for Dehydroacetic acid?
Dehydroacetic acid (CAS 520-45-6) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dehydroacetic acid
Also known as: 3-Acetyl-6-methyl-2,4-pyrandione, 3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione, DHS, Geogard 111A, Dehydracetic acid (+15 more)
CAS 520-45-6
Dehydroacetic acid (CAS 520-45-6) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
10
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Dehydroacetic acid
CAS Number
520-45-6
DTXSID
DTXSID6020014
Molecular Formula
C8H8O4
InChI Key
PGRHXDWITVMQBC-UHFFFAOYSA-N
Monoisotopic Mass
168.042259
Synonyms
3-Acetyl-6-methyl-2,4-pyrandione3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dioneDHSGeogard 111ADehydracetic acid4-17-00-066993-Acetyl-4-hydroxy-6-methyl-2H-pyran-2-one2-Acetyl-5-hydroxy-3-oxo-4-hexenoic acid, delta-lactone3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione. enol formBRN 0006129Caswell No. 278DHA (VAN)
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 * | H302 | GHS07 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
22 records
BiocidePreservativeFragranceAntioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
10 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10.99 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2KAG279R6R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2KAG279R6R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2KAG279R6R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2KAG279R6R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione | 208-293-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.6%
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1724669
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 0.6 mg/kg bw
View full food safety profile →Frequently Asked Questions
What is the NOAEL for Dehydroacetic acid?
Dehydroacetic acid has 6 NOAEL studies in the database. The lowest reported value is 10.99 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include Dehydroacetic acid?
Dehydroacetic acid appears on 9 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, detected; Europe; Personal care - sexual wellness, and 6 more. Source: EPA CPDat.
Is Dehydroacetic acid used in cosmetics?
Yes, Dehydroacetic acid is also indexed as a cosmetic ingredient under the name Dehydroacetic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dehydroacetic acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Dehydroacetic acid used outside industrial chemicals?
Dehydroacetic acid also appears in cosmetics, pharmaceutical, food safety databases.