Good Preservative Sensitization Data Dermal Penetration

Dehydroacetic Acid

INCI: DEHYDROACETIC ACID

CAS Number
520-45-6
Function
Preservative; broad-spectrum antimicrobial (bacteria, fungi, yeasts)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 0.6%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted without specific cosmetic concentration cap under FDA. Listed in FDA Inactive Ingredients Database for topical use. No specific MoCRA restriction. Sodium dehydroacetate (the sodium salt form) is the most commonly used form in cosmetic formulations.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Dehydroacetic Acid based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
0.1%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis

Source: ESSCA; IVDK; NACDG

Dermal Penetration Profile

Skin absorption and penetration characteristics of Dehydroacetic Acid, relevant to systemic exposure and MoS calculations.

Absorption %
6-12%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum/epidermis
Molecular Weight
168.1 Da
Log P
0.52
Systemic Absorption
minimal
Topical Bioavailability
4-10%
Safety Margin Factor
moderate
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: SCCS Opinion

Expert Verdict

Dehydroacetic acid (DHA) is an EU Annex V-listed synthetic preservative with broader pH activity than organic acid preservatives, effective from pH 3 to approximately 7. EU max 0.6% as acid; prohibited in aerosols due to inhalation concern. Most commonly formulated as sodium dehydroacetate for improved solubility. Broad-spectrum activity against bacteria, fungi, and yeasts. Frequently combined with benzyl alcohol in COSMOS-approved preservation systems.

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Concern Level: Low

Regulatory Flags

eu-annex-v restricted aerosol-prohibited broad-ph-range broad-spectrum sodium-salt-form cosmos-benzyl-alcohol-pair epa_safer_alternative fda_food_additive

Frequently Asked Questions

Is Dehydroacetic Acid safe in cosmetics?

Dehydroacetic acid (DHA) is an EU Annex V-listed synthetic preservative with broader pH activity than organic acid preservatives, effective from pH 3 to approximately 7. EU max 0.6% as acid; prohibited in aerosols due to inhalation concern. Most commonly formulated as sodium dehydroacetate for improved solubility. Broad-spectrum activity against bacteria, fungi, and yeasts. Frequently combined with benzyl alcohol in COSMOS-approved preservation systems. The EU classifies Dehydroacetic Acid as "restricted". Safety rating: GOOD.

Is Dehydroacetic Acid allowed in the EU?

Dehydroacetic Acid EU regulatory status: restricted. Maximum allowed concentration: 0.6%. This is based on EU Regulation 1223/2009 and its amendments.

What does Dehydroacetic Acid do in cosmetics?

Dehydroacetic Acid functions as: Preservative; broad-spectrum antimicrobial (bacteria, fungi, yeasts). It is classified as a Preservative in our database. CAS number: 520-45-6.

What is the Margin of Safety for Dehydroacetic Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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