NOAEL Data Cosmetic Ingredient

2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione

Also known as: EINECS 257-687-7, UNII-578544UDFJ

CAS 52136-25-1

2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione (CAS 52136-25-1) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for HC Green No. 1 →

SOURCE noael studies public
NOAEL studies
27
SOURCE chemical inventory jurisdictions
Regulatory lists
1
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields
Name
2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione
CAS Number
52136-25-1
DTXSID
DTXSID60200145
Molecular Formula
C18H23N3O5
InChI Key
BZYZOJIGZUACMS-UHFFFAOYSA-N
Monoisotopic Mass
361.163771
Synonyms
EINECS 257-687-7UNII-578544UDFJ

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
banned; Europe; Personal careEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 27 of 27 studies
ValueUnitEndpointRouteSpeciesSource
578544UDFJUNIIFDA UNII substance identifier--openFDA substances
578544UDFJUNIIFDA UNII substance identifier--openFDA substances
578544UDFJUNIIFDA UNII substance identifier--openFDA substances
578544UDFJUNIIFDA UNII substance identifier--openFDA substances
=100mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=100mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=100mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=100mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=100.7%NOAELdermalhumanSCCNFP_vision_codex
=100.7%NOAELdermalhumanSCCNFP_vision_codex
=100.7%NOAELdermalhumanSCCNFP_vision_codex
=100.7%NOAELdermalhumanSCCNFP_vision_codex
=300mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=300mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=300mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=300mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=1000mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=1000mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=1000mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=1000mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
100.7%dermal absorptiondermalhumanUnifiedCodex:SCCNFP:beta.noael_studies
100.7%dermal absorptiondermalhumanUnifiedCodex:SCCNFP:beta.noael_studies
100.7%dermal absorptiondermalhumanUnifiedCodex:SCCNFP:beta.noael_studies
1000mg/kg bw/daydermal absorption-ratUnifiedCodex:SCCNFP:beta.noael_studies
100mg/kg bw/dayirritationoralratUnifiedCodex:SCCNFP:beta.noael_studies
100mg/kg bw/dayrepeated dose toxicitydermalratUnifiedCodex:SCCNFP:beta.noael_studies
300mg/kg bw/dayrepeated dose toxicitydermalratUnifiedCodex:SCCNFP:beta.noael_studies

Showing 27 of 27 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione?

2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione has 27 NOAEL studies in the database. The lowest reported value is 578544UDFJ UNII. Source: openFDA substances.

What regulatory lists include 2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione?

2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.

Is 2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione used in cosmetics?

Yes, 2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione is also indexed as a cosmetic ingredient under the name HC Green No. 1. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione used outside industrial chemicals?

2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione also appears in cosmetics databases.