Is HC Green No. 1 safe in cosmetics?
HC Green No. 1 has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Green No. 1
Also known as: EINECS 257-687-7, UNII-578544UDFJ
HC Green No. 1 (CAS 52136-25-1) is a cosmetic cosmetic ingredient functioning as Dye. Reported NOAEL =100 mg/kg bw/day in rat (SCCNFP_vision_codex); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 52136-25-1 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
2-[4-[bis(2-hydroxyethyl)amino]anilino]-5-(2-hydroxyethylamino)cyclohexa-2,5-diene-1,4-dione
InChIKey
BZYZOJIGZUACMS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted under coal-tar hair dye exemption (FD&C Act §601(a)); not separately listed under 21 CFR 73/74
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Green No. 1.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Green No. 1. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =300 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =300 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =300 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =300 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg bw/day | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg bw/day | - | rat | dermal absorption | SCCNFP_vision_codex |
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1238
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1238
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Green No. 1.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Green No. 1 by CAS number or substance name.
Studies
12
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
SCCNFP_vision_codex
Known Synonyms
EINECS 257-687-7
UNII-578544UDFJ
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Frequently Asked Questions
Is HC Green No. 1 allowed in the EU?
HC Green No. 1 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Green No. 1 do in cosmetics?
HC Green No. 1 functions as: Dye. It is classified as a cosmetic ingredient in our database. CAS number: 52136-25-1.
What is the NOAEL for HC Green No. 1?
The NOAEL (No Observed Adverse Effect Level) for HC Green No. 1 is =100 mg/kg bw/day based on a repeated dose toxicity study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Compliance Tools
Check HC Green No. 1 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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