What is the NOAEL for 2,3-Dimethylphenol?
2,3-Dimethylphenol has 7 NOAEL studies in the database. The lowest reported value is 40.7 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,3-Dimethylphenol
Also known as: 4-06-00-03096, Benzene, 1,2-dimethyl-3-hydroxy-, BRN 1906267, EINECS 208-395-3, Vic-o-Xylenol (+3 more)
CAS 526-75-0
2,3-Dimethylphenol (CAS 526-75-0) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for 2,3-Xylenol (2,3-Dimethylphenol) →
Cross-Vertical Regulatory Divergence
2,3-Dimethylphenol is classified GHS Danger (H301, H311, H314, H318, H411) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
2,3-Dimethylphenol
CAS Number
526-75-0
DTXSID
DTXSID6025143
Molecular Formula
C8H10O
InChI Key
QWBBPBRQALCEIZ-UHFFFAOYSA-N
Monoisotopic Mass
122.073165
Synonyms
4-06-00-03096Benzene, 1,2-dimethyl-3-hydroxy-BRN 1906267EINECS 208-395-3Vic-o-XylenolXyellenol 100o-3-XylenolUNII-RLF9YS3586
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 40.7 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| RLF9YS3586 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RLF9YS3586 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RLF9YS3586 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RLF9YS3586 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =1000 | mM | NOEL | dermal | Mouse | ToxValDB_ECOTOX |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,3-xylenol | 208-395-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1490403
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2,3-Dimethylphenol?
2,3-Dimethylphenol appears on 3 regulatory/inventory lists including air; detected; emissions; Europe; Other direct contact consumer goods, IFRA Transparency, Europe. Source: EPA CPDat.
Is 2,3-Dimethylphenol used in cosmetics?
Yes, 2,3-Dimethylphenol is also indexed as a cosmetic ingredient under the name 2,3-Xylenol (2,3-Dimethylphenol). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,3-Dimethylphenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,3-Dimethylphenol have different safety status in cosmetics vs industrial chemicals?
2,3-Dimethylphenol is classified GHS Danger (H301, H311, H314, H318, H411) in the chemicals database but is allowed in EU cosmetics.
Is 2,3-Dimethylphenol used outside industrial chemicals?
2,3-Dimethylphenol also appears in cosmetics, pharmaceutical, cannabis databases.