What is the NOAEL for 2-Hydroxyethyl methacrylate phosphate?
2-Hydroxyethyl methacrylate phosphate has 12 NOAEL studies in the database. The lowest reported value is 7.04 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Hydroxyethyl methacrylate phosphate
Also known as: 2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, phosphate, 2-Hydroxyethylmethacrylate phosphoric acid partial ester, Ethylene glycol methacrylate phosphate, EINECS 258-053-2, Hydroxyethyl methacrylate, phosphated (+1 more)
CAS 52628-03-2
2-Hydroxyethyl methacrylate phosphate (CAS 52628-03-2) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Methacryloylethyl Phosphate →
Cross-Vertical Regulatory Divergence
2-Hydroxyethyl methacrylate phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H314, H315, H317, H318, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
2-Hydroxyethyl methacrylate phosphate
CAS Number
52628-03-2
DTXSID
DTXSID4044951
Synonyms
2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, phosphate2-Hydroxyethylmethacrylate phosphoric acid partial esterEthylene glycol methacrylate phosphateEINECS 258-053-2Hydroxyethyl methacrylate, phosphated2-Hydroxyethyl 2-methyl-2-propenoate, phosphate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
Softener and conditioner
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =7.04 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| P8914Q0ZMM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8914Q0ZMM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8914Q0ZMM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8914Q0ZMM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5621 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >1000 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, phosphate | 258-053-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Frequently Asked Questions
Is 2-Hydroxyethyl methacrylate phosphate used in cosmetics?
Yes, 2-Hydroxyethyl methacrylate phosphate is also indexed as a cosmetic ingredient under the name Methacryloylethyl Phosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Hydroxyethyl methacrylate phosphate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Hydroxyethyl methacrylate phosphate have different safety status in cosmetics vs industrial chemicals?
2-Hydroxyethyl methacrylate phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H314, H315, H317, H318, H335).
Is 2-Hydroxyethyl methacrylate phosphate used outside industrial chemicals?
2-Hydroxyethyl methacrylate phosphate also appears in cosmetics databases.