Is Methacryloylethyl Phosphate safe in cosmetics?
Methacryloylethyl Phosphate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Methacryloylethyl Phosphate
Also known as: 2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, phosphate, 2-Hydroxyethylmethacrylate phosphoric acid partial ester, Ethylene glycol methacrylate phosphate, EINECS 258-053-2, Hydroxyethyl methacrylate, phosphated (+1 more)
INCI: METHACRYLOYLETHYL PHOSPHATE
Methacryloylethyl Phosphate (CAS 52628-03-2) is a cosmetic cosmetic ingredient functioning as Nail conditioning. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 52628-03-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Methacryloylethyl Phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H314, H315, H317, H318, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Nail conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-hydroxyethyl 2-methylprop-2-enoate;phosphoric acid
InChIKey
POLZHVHESHDZRD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Allowed - not specifically restricted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methacryloylethyl Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Methacryloylethyl Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Methacryloylethyl Phosphate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Methacryloylethyl Phosphate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Methacryloylethyl Phosphate by CAS number or substance name.
Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, phosphate
2-Hydroxyethylmethacrylate phosphoric acid partial ester
Ethylene glycol methacrylate phosphate
EINECS 258-053-2
Hydroxyethyl methacrylate, phosphated
2-Hydroxyethyl 2-methyl-2-propenoate, phosphate
Chemical Function
Softener and conditioner
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Methacryloylethyl Phosphate allowed in the EU?
Methacryloylethyl Phosphate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methacryloylethyl Phosphate do in cosmetics?
Methacryloylethyl Phosphate functions as: Nail conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 52628-03-2.
What is the NOAEL for Methacryloylethyl Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Methacryloylethyl Phosphate is =300 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Methacryloylethyl Phosphate used outside cosmetics?
Methacryloylethyl Phosphate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Methacryloylethyl Phosphate have different safety status in cosmetics vs industrial chemicals?
Methacryloylethyl Phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H314, H315, H317, H318, H335).
Compliance Tools
Check Methacryloylethyl Phosphate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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