Also known as: Methyl N,N,N-trimethyl-4-((4,7,7-trimethyl-3-oxobicyclo(2.2.1)hept-2-ylidene)methyl)anilinium sulphate, Benzenaminium, N,N,N-trimethyl-4-((4,7,7-trimethyl-3-oxobicyclo(2.2.1)hept-2-ylidene)methyl)-, methyl sulfate, EINECS 258-190-8
CAS 52793-97-2
4-((2-Oxo-3-bornylidene)methyl)-phenyltrimethylammonium methylsulfate (CAS 52793-97-2) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.
View cosmetic safety profile for Camphor Benzalkonium Methosulfate →
CAS, identifiers, formula, and alternate names for the matched substance record.
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 300 | mg/kg/day | - | oral | rat | Regulatory source |
| 300 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.819 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| =3 | % | NOAEL | dermal | - | SCCS Opinion |
| =89.1 | mg/kg bw | NOAEL | oral | rat | SCCS Opinion |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =300 | mg/kg/day | NOAEL | oral | rat | SCCS Opinion |
| =1000 | mg/kg/day | NOAEL | - | rat | SCCS Opinion |
| =0.819 | mg/kg | dermal absorption | oral | rat | Regulatory source |
| 3 | % | dermal absorption | dermal | - | Regulatory source |
| =89.1 | mg/kg bw | dermal absorption | oral | rat | Regulatory source |
| 300 | mg/kg/day | developmental toxicity | - | guinea pig | Regulatory source |
| 1000 | mg/kg/day | developmental toxicity | - | rat | Regulatory source |
| 1000 | mg/kg/day | developmental toxicity | dermal | guinea pig | Regulatory source |
| 300 | mg/kg/day | genotoxicity | oral | rat | Regulatory source |
Showing 15 of 15 studies
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1430/11 | 20 September 2011 | 3% (revised downward from 6% due to low oral bioavailability concerns) | Low oral bioavailability indications via subcutaneous lethality data; addendum requires revised MoS calculation; borderline safety margin at 6% reconsidered | |
| SCCP/1203/08 | 21 January 2009 | 3% (as revised); 6% was original conclusion but subsequently corrected | Borderline MoS at 3%; low oral bioavailability concern identified post-opinion; adsorption via inhalation not assessed; subsequent addendum (SCCS/1445/11) lowered effective limit | |
| SCCP/0997/06 | 19 December 2006 | safe | up to 6% in sunscreen products (first submission opinion) | Borderline MoS; requires new dermal absorption study per SCCNFP guidance before reconsideration; eye irritation noted at 20% aqueous solution |
| SCCP/1015/06 | 2006-12-19 | Based on the information provided, the SCCP is of the opinion that the use of camphor benzalkonium methosulphate as a UV-filter at a maximum concentration of 6.0% in the cosmetic sun protection preparations does not pose a risk to the health of the consumer. Because of its borderline Margin of Safety, its use in other types of cosmetic products is not recommended. | 6.0% | Borderline Margin of Safety; figure includes an outlier; a new dermal absorption study is required before any reconsideration (COLIPA S57, Mexoryl SO). |
Same-CAS cosmetic ingredient record for cross-vertical context.
4-((2-Oxo-3-bornylidene)methyl)-phenyltrimethylammonium methylsulfate has 15 NOAEL studies in the database. The lowest reported value is 0.819 mg/kg via oral in rat. Source: SCCS Opinion.
4-((2-Oxo-3-bornylidene)methyl)-phenyltrimethylammonium methylsulfate appears on 1 regulatory/inventory list including Europe; Personal care. Source: EPA CPDat.
Yes, 4-((2-Oxo-3-bornylidene)methyl)-phenyltrimethylammonium methylsulfate is also indexed as a cosmetic ingredient under the name Camphor Benzalkonium Methosulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
4-((2-Oxo-3-bornylidene)methyl)-phenyltrimethylammonium methylsulfate also appears in cosmetics databases.