Moderate Cosmetic Ingredient NOAEL Data

Camphor Benzalkonium Methosulfate

INCI: CAMPHOR BENZALKONIUM METHOSULFATE

CAS Number
52793-97-2
Function
Antimicrobial, Antistatic, UV Absorber, UV Filter
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 6%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Borderline margin of safety at 6%. Applicant requested reduction to 3% max to improve margin of safety.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Camphor Benzalkonium Methosulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 100 mg/kg bw/day oral rat Subchronic COSMOS_DB
LOAEL 300 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Borderline margin of safety per SCCP opinion; restricted to sunscreen products only with dermal absorption data deemed insufficient for broader use expansion.

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Concern Level: Moderate

Regulatory Flags

eu_cosing_listed

Frequently Asked Questions

Is Camphor Benzalkonium Methosulfate safe in cosmetics?

Borderline margin of safety per SCCP opinion; restricted to sunscreen products only with dermal absorption data deemed insufficient for broader use expansion. The EU classifies Camphor Benzalkonium Methosulfate as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is Camphor Benzalkonium Methosulfate allowed in the EU?

Camphor Benzalkonium Methosulfate EU regulatory status: restricted. Maximum allowed concentration: 6%. This is based on EU Regulation 1223/2009 and its amendments.

What does Camphor Benzalkonium Methosulfate do in cosmetics?

Camphor Benzalkonium Methosulfate functions as: Antimicrobial, Antistatic, UV Absorber, UV Filter. It is classified as a cosmetic ingredient in our database. CAS number: 52793-97-2.

What is the Margin of Safety for Camphor Benzalkonium Methosulfate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Camphor Benzalkonium Methosulfate?

The NOAEL (No Observed Adverse Effect Level) for Camphor Benzalkonium Methosulfate is 100 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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