NOAEL Data Cosmetic Ingredient

Magnolol

Also known as: 5,5'-Diallyl-2,2'-dihydroxybiphenyl, NSC 293099, UNII-001E35HGVF

CAS 528-43-8

Magnolol (CAS 528-43-8) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Magnolol →

Cross-Vertical Regulatory Divergence

Magnolol is classified GHS Danger (H315, H318, H319, H335, H411) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields

Name

Magnolol

CAS Number

528-43-8

DTXSID

DTXSID0044076

Molecular Formula

C18H18O2

InChI Key

VVOAZFWZEDHOOU-UHFFFAOYSA-N

Monoisotopic Mass

266.13068

Synonyms

5,5'-Diallyl-2,2'-dihydroxybiphenylNSC 293099UNII-001E35HGVF

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

AntioxidantBleaching agentFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies

Value	Unit	Endpoint	Route	Species	Source
001E35HGVF	UNII	FDA UNII substance identifier	-	-	openFDA substances
001E35HGVF	UNII	FDA UNII substance identifier	-	-	openFDA substances
001E35HGVF	UNII	FDA UNII substance identifier	-	-	openFDA substances
001E35HGVF	UNII	FDA UNII substance identifier	-	-	openFDA substances

Showing 4 of 4 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL MAGNOLOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for Magnolol?

Magnolol has 4 NOAEL studies in the database. The lowest reported value is 001E35HGVF UNII. Source: openFDA substances.

What regulatory lists include Magnolol?

Magnolol appears on 1 regulatory/inventory list including food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.

Is Magnolol used in cosmetics?

Yes, Magnolol is also indexed as a cosmetic ingredient under the name Magnolol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Magnolol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Does Magnolol have different safety status in cosmetics vs industrial chemicals?

Magnolol is classified GHS Danger (H315, H318, H319, H335, H411) in the chemicals database but is allowed in EU cosmetics.

Is Magnolol used outside industrial chemicals?

Magnolol also appears in cosmetics, pharmaceutical, food safety databases.