Magnolol

INCI: MAGNOLOL

CAS Number
528-43-8
Function
Antioxidant, anti-inflammatory, skin brightening (tyrosinase inhibitor), antimicrobial/antifungal
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed. No prohibitions or restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Generally considered safe at typical cosmetic use levels. Heat-sensitive - degradation can occur with prolonged heating above 80 °C, requiring careful formulation handling. No significant irritancy or sensitization reported at standard concentrations. A biphenolic lignan isolated from Magnolia officinalis bark. Potent free radical scavenger that mitigates UV-induced oxidative stress. Inhibits melanin synthesis for skin-whitening effects. Also demonstrates muscle-relaxant and platelet aggregat...

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen fda_food_additive jecfa_safe

Frequently Asked Questions

Is Magnolol safe in cosmetics?

Generally considered safe at typical cosmetic use levels. Heat-sensitive - degradation can occur with prolonged heating above 80 °C, requiring careful formulation handling. No significant irritancy or sensitization reported at standard concentrations. A biphenolic lignan isolated from Magnolia officinalis bark. Potent free radical scavenger that mitigates UV-induced oxidative stress. Inhibits melanin synthesis for skin-whitening effects. Also demonstrates muscle-relaxant and platelet aggregat... The EU classifies Magnolol as "permitted". Safety rating: MODERATE.

Is Magnolol allowed in the EU?

Magnolol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Magnolol do in cosmetics?

Magnolol functions as: Antioxidant, anti-inflammatory, skin brightening (tyrosinase inhibitor), antimicrobial/antifungal. It is classified as a cosmetic ingredient in our database. CAS number: 528-43-8.

What is the Margin of Safety for Magnolol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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