NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

2-Nitro-1,4-phenylenediamine

Also known as: 2-Nitro-p-phenylenediamine, 3-13-00-00271, BRN 2210195, CI Oxidation Base 22, Durafur Brown (+12 more)

CAS 5307-14-2

2-Nitro-1,4-phenylenediamine (CAS 5307-14-2) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC.

View cosmetic safety profile for 2-Nitro-P-Phenylenediamine →

Cross-Vertical Regulatory Divergence

2-Nitro-1,4-phenylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H335, H302).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields

Name

2-Nitro-1,4-phenylenediamine

CAS Number

5307-14-2

Molecular Formula

C6H7N3O2

InChI Key

HVHNMNGARPCGGD-UHFFFAOYSA-N

Monoisotopic Mass

153.053826

Synonyms

2-Nitro-p-phenylenediamine3-13-00-00271BRN 2210195CI Oxidation Base 22Durafur BrownEINECS 226-164-5NCI-C022222-Nitrol-para-phenylenediamine2-Nitrol-p-phenylenediamineOxidation Base 221,4-DiaminonitrobenzolUNII-PV83F3C01Q

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	1992	Sup 7, 57

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
Long-term Effects	Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure	The substance can be absorbed into the body through the skin.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 25 of 25 studies

Value	Unit	Endpoint	Route	Species	Source
276.7	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
5.42	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
6.8	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
115.5	ug/mL	CV70	Dermal	-	NTP ICE skin sensitization
490.7	ug/mL	CV75	Dermal	-	NTP ICE skin sensitization
93.3	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
99.2	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
0	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
5.7	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
46.7	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
50	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
11.46	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
0.4	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
786.4	uM	EC3	Dermal	-	NTP ICE skin sensitization
PV83F3C01Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP ICE cancer
>2000	uM	IC50	Dermal	-	NTP ICE skin sensitization
4.53	ratio	Imax	Dermal	-	NTP ICE skin sensitization
=1800	mg/kg bw	LD50	oral	Rat (Male/Female)	NTP ICE acute oral
=2100	mg/kg bw	LD50	oral	Rat (Male)	NTP ICE acute oral
=3080	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
1100	ppm	Top dose	-	Rat	NTP ICE cancer
2200	ppm	Top dose	-	Rat	NTP ICE cancer
4400	ppm	Top dose	-	Mouse	NTP ICE cancer

Showing 25 of 25 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	2-nitro-p-phenylenediamine	226-164-5	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL353971

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-Nitro-1,4-phenylenediamine?

2-Nitro-1,4-phenylenediamine has 25 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP ICE skin sensitization.

Is 2-Nitro-1,4-phenylenediamine a carcinogen according to IARC?

2-Nitro-1,4-phenylenediamine is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1992). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is 2-Nitro-1,4-phenylenediamine used in cosmetics?

Yes, 2-Nitro-1,4-phenylenediamine is also indexed as a cosmetic ingredient under the name 2-Nitro-P-Phenylenediamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Nitro-1,4-phenylenediamine come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Nitro-1,4-phenylenediamine have different safety status in cosmetics vs industrial chemicals?

2-Nitro-1,4-phenylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H335, H302).

Is 2-Nitro-1,4-phenylenediamine used outside industrial chemicals?

2-Nitro-1,4-phenylenediamine also appears in cosmetics, pharmaceutical databases.