What is the NOAEL for 2-Nitro-1,4-phenylenediamine?
2-Nitro-1,4-phenylenediamine has 31 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
2-Nitro-1,4-phenylenediamine
Also known as: 2-Nitro-p-phenylenediamine, 3-13-00-00271, BRN 2210195, CI Oxidation Base 22, Durafur Brown (+12 more)
CAS 5307-14-2
2-Nitro-1,4-phenylenediamine (CAS 5307-14-2) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC.
View cosmetic safety profile for 2-Nitro-P-Phenylenediamine →
Cross-Vertical Regulatory Divergence
2-Nitro-1,4-phenylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H335, H302).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
31
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
2-Nitro-1,4-phenylenediamine
CAS Number
5307-14-2
DTXSID
DTXSID4020957
Molecular Formula
C6H7N3O2
InChI Key
HVHNMNGARPCGGD-UHFFFAOYSA-N
Monoisotopic Mass
153.053826
Synonyms
2-Nitro-p-phenylenediamine3-13-00-00271BRN 2210195CI Oxidation Base 22Durafur BrownEINECS 226-164-5NCI-C022222-Nitrol-para-phenylenediamine2-Nitrol-p-phenylenediamineOxidation Base 221,4-DiaminonitrobenzolUNII-PV83F3C01Q
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1992 | Sup 7, 57 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body through the skin. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 31 of 31 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 276.7 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 5.42 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 6.8 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 115.49 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 490.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 93.3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 99.2 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 5.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 46.7 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 50 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 11.464 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 786.4 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| PV83F3C01Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PV83F3C01Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PV83F3C01Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PV83F3C01Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >2000 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 4.53 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| =1800 | mg/kg bw | LD50 | oral | Rat (Male/Female) | NTP_ICE_acute_oral |
| =2100 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =3080 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 1100 | ppm | Top dose | - | Rat | NTP_ICE_cancer |
| 2200 | ppm | Top dose | - | Rat | NTP_ICE_cancer |
| 4400 | ppm | Top dose | - | Mouse | NTP_ICE_cancer |
Showing 31 of 31 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-nitro-p-phenylenediamine | 226-164-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL353971
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
Is 2-Nitro-1,4-phenylenediamine a carcinogen according to IARC?
2-Nitro-1,4-phenylenediamine is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1992). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is 2-Nitro-1,4-phenylenediamine used in cosmetics?
Yes, 2-Nitro-1,4-phenylenediamine is also indexed as a cosmetic ingredient under the name 2-Nitro-P-Phenylenediamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Nitro-1,4-phenylenediamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Nitro-1,4-phenylenediamine have different safety status in cosmetics vs industrial chemicals?
2-Nitro-1,4-phenylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H335, H302).
Is 2-Nitro-1,4-phenylenediamine used outside industrial chemicals?
2-Nitro-1,4-phenylenediamine also appears in cosmetics, pharmaceutical databases.