Is 2-Nitro-P-Phenylenediamine safe in cosmetics?
2-Nitro-P-Phenylenediamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. This ingredient has been reviewed by cir.
2-Nitro-P-Phenylenediamine
Also known as: 3-13-00-00271, BRN 2210195, CI Oxidation Base 22, Durafur Brown, EINECS 226-164-5 (+11 more)
INCI: 2-NITRO-P-PHENYLENEDIAMINE
2-Nitro-P-Phenylenediamine (CAS 5307-14-2) is a cosmetic cosmetic ingredient functioning as Hair dye (non-oxidative). EU Regulation 1223/2009 status: prohibited; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 5307-14-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Nitro-P-Phenylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H335, H302).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dye (non-oxidative)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-nitrobenzene-1,4-diamine
InChIKey
HVHNMNGARPCGGD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted under the coal tar hair dye exemption; CIR Expert Panel reviewed and concluded safe in present practices of use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Nitro-P-Phenylenediamine.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body through the skin.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Number
3, 1985
Verdict: unknown
Sensitization Profile
Contact sensitization data for 2-Nitro-P-Phenylenediamine based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: IVDK; NACDG; ESSCA
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
Sup 7, 57
Evaluation Year
1992
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
96.25%
DPRA Lys %
2.85%
KeratinoSens IC50
2000 µM
hCLAT CV75
490.7 µg/mL
LLNA EC3
0.4%
NESIL
100 µg/cm²
LLNA: Strong (1A)
GHS: 1A
Source: LLNA: Gerberick et al. (2005); DPRA: Nukada et al. 2013 [DOI:10.1016/j.tiv.2012.11.006] | Natsch et al. 2013 [DOI:10.1002/jat.2868]; KS: Natsch et al. 2013 [DOI:10.1002/jat.2868]; hCLAT: Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Korea (Prohibited): Reclassified prohibited for hair dyes (2024)
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | restricted | 3.0 | oxidative hair dye only |
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
EPA Dryad Skin Absorption (physics-based)
MW: 153.139
LogP: 0.533347
Kp epidermis: 0.00534 cm/h
% dose epidermis: 0.98%
% dose stratum corneum: 0.98%
% dose dermis: 0.98%
Source: EPA_Dryad_Skin_Absorption_2024
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "cross_reactivity_group": "para-amino-group", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; NACDG; ESSCA"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
1,4-Diamino-2-nitrobenzene | Group 3: Not classifiable as to its carcinogenicity to humans | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 57: (1993) Occupational Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industria
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
2-Nitro-p-phenylenediamine | TR-169: Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CASRN 5307-14-2) (1979 ) | 08/31/78 | No Evidence | No Evidence | No Evidence | Clear Evidence | Under the conditions of this bioassay, dietary administration of 2-nitro-p-phenylenediamine was carcinogenic to female B6C3F1 mice, causing an increased incidence of hepatocellular neoplas
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation: There is no data for humans. There is inadequate evidence of the carcinogenicity of 1,4-diamino-2-nitrobenzene in animals. OVERALL EVALUATION: Group 3: 1,4-diamino-2-nitrobenzene is not classifiable as to its carcinogenicity to humans.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
1542
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for 2-Nitro-P-Phenylenediamine.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-Nitro-P-Phenylenediamine by CAS number or substance name.
Studies
36
Lowest NOAEL
55 mg/kg bw/day
Highest NOAEL
4000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
3-13-00-00271
BRN 2210195
CI Oxidation Base 22
Durafur Brown
EINECS 226-164-5
NCI-C02222
2-Nitrol-para-phenylenediamine
2-Nitrol-p-phenylenediamine
Oxidation Base 22
1,4-Diaminonitrobenzol
UNII-PV83F3C01Q
2-NPPD
2-nitro-4-phenylenediamine
2NDB
C.I. 76070
CI 76070
Chemical Function
Dye
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL353971
Frequently Asked Questions
Is 2-Nitro-P-Phenylenediamine allowed in the EU?
2-Nitro-P-Phenylenediamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Nitro-P-Phenylenediamine do in cosmetics?
2-Nitro-P-Phenylenediamine functions as: Hair dye (non-oxidative). It is classified as a cosmetic ingredient in our database. CAS number: 5307-14-2.
Is 2-Nitro-P-Phenylenediamine used outside cosmetics?
2-Nitro-P-Phenylenediamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Nitro-P-Phenylenediamine have different safety status in cosmetics vs industrial chemicals?
2-Nitro-P-Phenylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H335, H302).
Compliance Tools
Check 2-Nitro-P-Phenylenediamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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