Poor Cosmetic Ingredient GHS Classified SCCS/CIR Reviewed Sensitization Data

2-Nitro-P-Phenylenediamine

INCI: 2-NITRO-P-PHENYLENEDIAMINE

CAS Number
5307-14-2
Function
Hair dye (non-oxidative)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under the coal tar hair dye exemption; CIR Expert Panel reviewed and concluded safe in present practices of use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body through the skin.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir Number 3, 1985
Verdict: unknown

Sensitization Profile

Contact sensitization data for 2-Nitro-P-Phenylenediamine based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis

Source: IVDK; NACDG; ESSCA

Expert Verdict

Prohibited in EU due to potential mutagenicity and sensitization concerns; permitted in US under coal tar hair dye exemption with established safe use practices.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is 2-Nitro-P-Phenylenediamine safe in cosmetics?

Prohibited in EU due to potential mutagenicity and sensitization concerns; permitted in US under coal tar hair dye exemption with established safe use practices. The EU classifies 2-Nitro-P-Phenylenediamine as "prohibited". Safety rating: POOR. This ingredient has been reviewed by cir.

Is 2-Nitro-P-Phenylenediamine allowed in the EU?

2-Nitro-P-Phenylenediamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Nitro-P-Phenylenediamine do in cosmetics?

2-Nitro-P-Phenylenediamine functions as: Hair dye (non-oxidative). It is classified as a cosmetic ingredient in our database. CAS number: 5307-14-2.

What is the Margin of Safety for 2-Nitro-P-Phenylenediamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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