What is the NOAEL for Esculin?
Esculin has 4 NOAEL studies in the database. The lowest reported value is 1Y1L18LQAF UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Esculin
Also known as: 2H-1-Benzopyran-2-one, 6-(beta-D-glucopyranosyloxy)-7-hydroxy-, 2H-1-Benzopyran-2-one, 6-(.beta.-D-glucopyranosyloxy)-7-hydroxy-, EINECS 208-517-5, Aesculetin glukosid, 7-Hydroxy-6-cumarinyl-glucosid (+9 more)
CAS 531-75-9
Esculin (CAS 531-75-9) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Esculin
CAS Number
531-75-9
DTXSID
DTXSID7045318
Molecular Formula
C15H16O9
InChI Key
XHCADAYNFIFUHF-TVKJYDDYSA-N
Monoisotopic Mass
340.079432
Synonyms
2H-1-Benzopyran-2-one, 6-(beta-D-glucopyranosyloxy)-7-hydroxy-2H-1-Benzopyran-2-one, 6-(.beta.-D-glucopyranosyloxy)-7-hydroxy-EINECS 208-517-5Aesculetin glukosid7-Hydroxy-6-cumarinyl-glucosid7-Hydroxy-6-glucosyloxy-2H-chromenNSC 26665UNII-1Y1L18LQAFVenoplant6,7-Dihydroxycoumarin-6-O-glucoside6-(beta-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one6-(beta-D-Glucopyranosyloxy)-7-hydroxy-cumarin
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
HumectantStabilizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1Y1L18LQAF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y1L18LQAF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y1L18LQAF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y1L18LQAF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Aesculin | 208-517-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Plant Extract
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ESCULIN
ChEMBL Phase
Not listed
Adverse Events
32
Bioactivity
2
Frequently Asked Questions
What regulatory lists include Esculin?
Esculin appears on 4 regulatory/inventory lists including children; Europe; Personal care, children; Europe; Personal care - dental care - toothpaste, Europe; Personal care, and 1 more. Source: EPA CPDat.
Is Esculin used in cosmetics?
Yes, Esculin is also indexed as a cosmetic ingredient under the name Esculin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Esculin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Esculin used outside industrial chemicals?
Esculin also appears in cosmetics, pharmaceutical databases.