Is Esculin safe in cosmetics?
Esculin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Esculin
INCI: ESCULIN
Esculin (CAS 531-75-9) is a cosmetic cosmetic ingredient functioning as Light Stabilizer, Tonic, Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 531-75-9 →
Auto-generated CPSR Part A draft with source citations
Function
Light Stabilizer, Tonic, Antioxidant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
InChIKey
XHCADAYNFIFUHF-TVKJYDDYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No CIR assessment published; no FDA restrictions under MoCRA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Esculin.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Esculin.
Regulatory Flags
coumarin-class-flag
no-dermal-absorption-data
no-sccs-opinion
no-cir-monograph
cpsr-data-gap
eu_children_restricted
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ESCULIN
ChEMBL ID
CHEMBL482581
Adverse Event Associations
32
Frequently Asked Questions
Is Esculin allowed in the EU?
Esculin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Esculin do in cosmetics?
Esculin functions as: Light Stabilizer, Tonic, Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 531-75-9.
Is Esculin used outside cosmetics?
Esculin also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Esculin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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