What is the NOAEL for Ethyl levulinate?
Ethyl levulinate has 8 NOAEL studies in the database. The lowest reported value is 7BU24CSS2G UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethyl levulinate
Also known as: Pentanoic acid, 4-oxo-, ethyl ester, 4-03-00-01562, BRN 0507641, EINECS 208-728-2, Ethyl acetylpropanoate (+9 more)
CAS 539-88-8
Ethyl levulinate (CAS 539-88-8) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Ethyl levulinate
CAS Number
539-88-8
DTXSID
DTXSID8047058
Molecular Formula
C7H12O3
InChI Key
GMEONFUTDYJSNV-UHFFFAOYSA-N
Monoisotopic Mass
144.078644
Synonyms
Pentanoic acid, 4-oxo-, ethyl ester4-03-00-01562BRN 0507641EINECS 208-728-2Ethyl acetylpropanoateEthyl 3-acetylpropionateEthyl ketovalerateEthyl 4-ketovalerateEthyl laevulinateEthyl levulateEthyl 4-oxopentanoateFEMA No. 2442
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 7BU24CSS2G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7BU24CSS2G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7BU24CSS2G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7BU24CSS2G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl 4-oxovalerate | 208-728-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3182933
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ethyl levulinate?
Ethyl levulinate appears on 5 regulatory/inventory lists including Europe, Australia; Food and drug - smoking-related products, IFRA Transparency, and 2 more. Source: EPA CPDat.
Is Ethyl levulinate used in cosmetics?
Yes, Ethyl levulinate is also indexed as a cosmetic ingredient under the name Ethyl Laevulinate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethyl levulinate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ethyl levulinate used outside industrial chemicals?
Ethyl levulinate also appears in cosmetics, pharmaceutical, cannabis databases.