Is Ethyl Laevulinate safe in cosmetics?
Ethyl Laevulinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Ethyl Laevulinate
Also known as: Pentanoic acid, 4-oxo-, ethyl ester, 4-03-00-01562, BRN 0507641, EINECS 208-728-2, Ethyl acetylpropanoate (+8 more)
Ethyl Laevulinate (CAS 539-88-8) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance; No specific technical function. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 539-88-8 →
Auto-generated CPSR Part A draft with source citations
Function
Flavouring and nutrient; Fragrance; No specific technical function
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
ethyl 4-oxopentanoate
InChIKey
GMEONFUTDYJSNV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS 2442; no specific cosmetic CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Laevulinate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
607
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL 4-OXOPENTANOATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL ACETYLPROPANOATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL LEVULINATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Laevulinate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Pentanoic acid, 4-oxo-, ethyl ester
4-03-00-01562
BRN 0507641
EINECS 208-728-2
Ethyl acetylpropanoate
Ethyl 3-acetylpropionate
Ethyl ketovalerate
Ethyl 4-ketovalerate
Ethyl levulate
Ethyl 4-oxopentanoate
FEMA No. 2442
NSC 24876
UNII-7BU24CSS2G
Chemical Function
Fragrance
No specific technical function
Flavouring and nutrient
Regulatory Lists
Europe
Australia; Food and drug - smoking-related products
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182933
Frequently Asked Questions
Is Ethyl Laevulinate allowed in the EU?
Ethyl Laevulinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Laevulinate do in cosmetics?
Ethyl Laevulinate functions as: Flavouring and nutrient; Fragrance; No specific technical function. It is classified as a cosmetic ingredient in our database. CAS number: 539-88-8.
Is Ethyl Laevulinate used outside cosmetics?
Ethyl Laevulinate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Laevulinate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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