What is the NOAEL for 2,4,5,6-Pyrimidinetetramine sulfate (1:1)?
2,4,5,6-Pyrimidinetetramine sulfate (1:1) has 14 NOAEL studies in the database. The lowest reported value is 3 unitless via Ocular in Rabbit. Source: NTP ICE eye irritation.
NOAEL Data
Cosmetic Ingredient
2,4,5,6-Pyrimidinetetramine sulfate (1:1)
Also known as: tetra-Aminopyrimidine sulfate, 2,4,5,6-Pyrimidinetetramine, sulfate (1:1), Pyrimidinetetramine, sulfate (1:1), 2,4,5,6-Tetraaminopyrimidine sulfate (1:1), NSC 227862 (+10 more)
CAS 5392-28-9
2,4,5,6-Pyrimidinetetramine sulfate (1:1) (CAS 5392-28-9) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.
View cosmetic safety profile for Tetraaminopyrimidine Sulfate →
SOURCE
NOAEL studies
NOAEL studies
14
SOURCE
Chemical inventory jurisdictions
Regulatory lists
2
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
2,4,5,6-Pyrimidinetetramine sulfate (1:1)
CAS Number
5392-28-9
Molecular Formula
C4H8N6.H2O4S
InChI Key
MQEFDQWUCTUJCP-UHFFFAOYSA-N
Monoisotopic Mass
238.048424
Synonyms
tetra-Aminopyrimidine sulfate2,4,5,6-Pyrimidinetetramine, sulfate (1:1)Pyrimidinetetramine, sulfate (1:1)2,4,5,6-Tetraaminopyrimidine sulfate (1:1)NSC 227862Sulfate de pyrimidinetetrayltetraaminepyrimidinetetrayltetraamine sulphatePyrimidintetrayltetraaminsulfatsulfato de pirimidinatetrailtetraamina2,4,5,6-Tetraaminopyrimidine sulfatetetraaminopyrimidine monosulfateEC 226-393-0
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 28 | - | - | - | - | Regulatory source |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 53QQY0I99M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =28 | - | NOAEL | - | - | SCCS Opinion |
| =150 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =375 | mg/kg/d | NOAEL | dermal | rat | SCCS Opinion |
| =375 | mg/kg bw/day | NOAEL | oral | rat | SCCS Opinion |
| =500 | mg/kg bw | NOAEL | oral | human | SCCS Opinion |
| =600 | mg/kg bw | NOAEL | oral | human | SCCS Opinion |
| 375 | mg/kg/d | developmental toxicity | dermal | rat | Regulatory source |
| 150 | mg/kg bw/d | repeated dose toxicity | oral | rat | Regulatory source |
| 375 | mg/kg bw/day | repeated dose toxicity | oral | rat | Regulatory source |
| 500 | mg/kg bw | repeated dose toxicity | oral | human | Regulatory source |
| 600 | mg/kg bw | repeated dose toxicity | oral | human | Regulatory source |
Showing 14 of 14 studies
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1118/07 | 2008-12-16 | The SCCP is of the opinion that the use of tetraaminopyrimidine sulfate as an ingredient in oxidative and non-oxidative hair dye formulations with a maximum on-head concentration of 3.4% (2.0% free base) does not pose a risk to the health of the consumer. | 3.4% on-head (2.0% free base) | A possible sensitising potential cannot be excluded. No mutagenic potential in vivo, but genotoxicity/mutagenicity studies on finished hair dye formulations should be undertaken. |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
3.4%
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3185354
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2,4,5,6-Pyrimidinetetramine sulfate (1:1)?
2,4,5,6-Pyrimidinetetramine sulfate (1:1) appears on 2 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring. Source: EPA CPDat.
Is 2,4,5,6-Pyrimidinetetramine sulfate (1:1) used in cosmetics?
Yes, 2,4,5,6-Pyrimidinetetramine sulfate (1:1) is also indexed as a cosmetic ingredient under the name Tetraaminopyrimidine Sulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,4,5,6-Pyrimidinetetramine sulfate (1:1) come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,4,5,6-Pyrimidinetetramine sulfate (1:1) used outside industrial chemicals?
2,4,5,6-Pyrimidinetetramine sulfate (1:1) also appears in cosmetics, pharmaceutical databases.