Is Tetraaminopyrimidine Sulfate safe in cosmetics?
Tetraaminopyrimidine Sulfate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Tetraaminopyrimidine Sulfate
Also known as: tetra-Aminopyrimidine sulfate, 2,4,5,6-Pyrimidinetetramine, sulfate (1:1), Pyrimidinetetramine, sulfate (1:1), 2,4,5,6-Tetraaminopyrimidine sulfate (1:1), NSC 227862 (+10 more)
INCI: TETRAAMINOPYRIMIDINE SULFATE
Tetraaminopyrimidine Sulfate (CAS 5392-28-9) is a cosmetic cosmetic ingredient functioning as Hair dyeing – oxidative dye precursor (reacts with couplers to form final dye). Reported NOAEL =150 mg/kg bw/d in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted, max 3.4%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 5392-28-9 →
Auto-generated CPSR Part A draft with source citations
Function
Hair dyeing – oxidative dye precursor (reacts with couplers to form final dye)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
pyrimidine-2,4,5,6-tetramine;sulfuric acid
InChIKey
MQEFDQWUCTUJCP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
3.4%
US US Status
permitted
US Notes
Permitted as coal tar hair dye under FD\&C Act exemptions (requires caution labeling and patch test instructions)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetraaminopyrimidine Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Tetraaminopyrimidine Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =150 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =150 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =150 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =150 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =375 mg/kg/d | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =375 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =375 mg/kg/d | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =375 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =375 mg/kg/d | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =375 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
100%
DPRA Lys %
22.1%
KeratinoSens IC50
2000 µM
hCLAT CV75
63 µg/mL
GHS: inconclusive
Source: DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products (c) Products intended for colouring eyelashes. Max: (b) 3,4% (calculated as sulphate).
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 3,4% (calculated as sulphate)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 0.5 | Oxidative hair dye products |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (3 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 2.65% | - | - | SCCP/0152 |
| measured | 0.25% | - | - | SCCP/0152 |
| measured | 0.48% | - | - | SCCP/0152 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Tetraaminopyrimidine Sulfate.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tetraaminopyrimidine Sulfate by CAS number or substance name.
Studies
20
Lowest NOAEL
150
Highest NOAEL
600
Units vary across source rows: mg/kg bw, mg/kg bw/d, mg/kg/d
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 2.65% | - | - |
| 0.25% | - | - |
| 0.48% | - | - |
Known Synonyms
tetra-Aminopyrimidine sulfate
2,4,5,6-Pyrimidinetetramine, sulfate (1:1)
Pyrimidinetetramine, sulfate (1:1)
2,4,5,6-Tetraaminopyrimidine sulfate (1:1)
NSC 227862
Sulfate de pyrimidinetetrayltetraamine
pyrimidinetetrayltetraamine sulphate
Pyrimidintetrayltetraaminsulfat
sulfato de pirimidinatetrailtetraamina
2,4,5,6-Tetraaminopyrimidine sulfate
tetraaminopyrimidine monosulfate
EC 226-393-0
EINECS 226-393-0
NSC 3277
Pyrimidine, tetraamino-, sulfate (1:1)
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Europe; Personal care - hair coloring
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185354
Frequently Asked Questions
Is Tetraaminopyrimidine Sulfate allowed in the EU?
Tetraaminopyrimidine Sulfate EU regulatory status: restricted. Maximum allowed concentration: 3.4%. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetraaminopyrimidine Sulfate do in cosmetics?
Tetraaminopyrimidine Sulfate functions as: Hair dyeing – oxidative dye precursor (reacts with couplers to form final dye). It is classified as a cosmetic ingredient in our database. CAS number: 5392-28-9.
What is the NOAEL for Tetraaminopyrimidine Sulfate?
The NOAEL (No Observed Adverse Effect Level) for Tetraaminopyrimidine Sulfate is =150 mg/kg bw/d based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is Tetraaminopyrimidine Sulfate used outside cosmetics?
Tetraaminopyrimidine Sulfate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tetraaminopyrimidine Sulfate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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