NOAEL Data Cosmetic Ingredient

4-[(Oxan-2-yl)oxy]phenol

CAS 53936-56-4

4-[(Oxan-2-yl)oxy]phenol (CAS 53936-56-4) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.

View cosmetic safety profile for Tetrahydropyranyloxy Phenol (Deoxyarbutin) →

SOURCE noael studies public
NOAEL studies
83
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields
Name
4-[(Oxan-2-yl)oxy]phenol
CAS Number
53936-56-4
DTXSID
DTXSID10968728
Molecular Formula
C11H14O3
InChI Key
GFBCWCDNXDKFRH-UHFFFAOYSA-N
Monoisotopic Mass
194.094294

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Bleaching agent

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 83 studies
ValueUnitEndpointRouteSpeciesSource
=15mg/kg/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=20mg/kg/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=74mg/kg/day-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
316mg/kg bw-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
316mg/kg bw-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
316mg/kg bw-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
RG969BY5ENUNIIFDA UNII substance identifier--openFDA substances
RG969BY5ENUNIIFDA UNII substance identifier--openFDA substances
RG969BY5ENUNIIFDA UNII substance identifier--openFDA substances
RG969BY5ENUNIIFDA UNII substance identifier--openFDA substances
=0.0218mg/kg bw/dayNOAELoralratSCCS_vision_codex
=0.0218mg/kg bw/dayNOAELoralratSCCS_vision_codex
=0.0218mg/kg bw/dayNOAELoralratSCCS_vision_codex
=0.0218mg/kg bw/dayNOAELoralratSCCS_vision_codex
=0.77mg/kgNOAELoralratSCCS_vision_codex
=0.77mg/kgNOAELoralratSCCS_vision_codex
=0.77mg/kgNOAELoralratSCCS_vision_codex
=0.77mg/kgNOAELoralratSCCS_vision_codex
=3%NOAELoralrabbitSCCS_vision_codex
=3%NOAELoralrabbitSCCS_vision_codex
=3%NOAELoralrabbitSCCS_vision_codex
=3%NOAELoralrabbitSCCS_vision_codex
=15mg/kg/dayNOAELoralratSCCS_vision_codex
=15mg/kg/dayNOAELoralratSCCS_vision_codex
=15mg/kg/dayNOAELoralratSCCS_vision_codex
=15mg/kg/dayNOAELoralratSCCS_vision_codex
=20mg/kg/dayNOAELoralratSCCS_vision_codex
=20mg/kg bw/dayNOAELoralratSCCS_vision_codex
=20mg/kg/dayNOAELoralratSCCS_vision_codex
=20mg/kg bw/dayNOAELoralratSCCS_vision_codex
=20mg/kg/dayNOAELoralratSCCS_vision_codex
=20mg/kg bw/dayNOAELoralratSCCS_vision_codex
=20mg/kg/dayNOAELoralratSCCS_vision_codex
=20mg/kg bw/dayNOAELoralratSCCS_vision_codex
=25mg/kg/dayNOAELoralratSCCS_vision_codex
=25mg/kg/dayNOAELoralratSCCS_vision_codex
=25mg/kg/dayNOAELoralratSCCS_vision_codex
=25mg/kg/dayNOAELoralratSCCS_vision_codex
=40%NOAELdermalrabbitSCCS_vision_codex
=40%NOAELdermalrabbitSCCS_vision_codex
=40%NOAELdermalrabbitSCCS_vision_codex
=40%NOAELdermalrabbitSCCS_vision_codex
=74mg/kg/dayNOAELoralratSCCS_vision_codex
=74mg/kg/dayNOAELoralratSCCS_vision_codex
=74mg/kg/dayNOAELoralratSCCS_vision_codex
=74mg/kg/dayNOAELoralratSCCS_vision_codex
=75mg/kg/dayNOAELoralratSCCS_vision_codex
=75mg/kg/dayNOAELoralratSCCS_vision_codex
=75mg/kg/dayNOAELoralratSCCS_vision_codex
=75mg/kg/dayNOAELoralratSCCS_vision_codex

Showing 50 of 83 studies

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1554/1525 June 2015insufficient dataNot determinedSkin lightening agent; potential for hydroquinone release; insufficient safety data provided

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL4303145
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 4-[(Oxan-2-yl)oxy]phenol?

4-[(Oxan-2-yl)oxy]phenol has 83 NOAEL studies in the database. The lowest reported value is 0.0218 mg/kg bw/day via oral in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

Is 4-[(Oxan-2-yl)oxy]phenol used in cosmetics?

Yes, 4-[(Oxan-2-yl)oxy]phenol is also indexed as a cosmetic ingredient under the name Tetrahydropyranyloxy Phenol (Deoxyarbutin). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-[(Oxan-2-yl)oxy]phenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 4-[(Oxan-2-yl)oxy]phenol used outside industrial chemicals?

4-[(Oxan-2-yl)oxy]phenol also appears in cosmetics, pharmaceutical databases.