NOAEL Data Cosmetic Ingredient

4-[(Oxan-2-yl)oxy]phenol

CAS 53936-56-4

4-[(Oxan-2-yl)oxy]phenol (CAS 53936-56-4) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.

View cosmetic safety profile for Tetrahydropyranyloxy Phenol (Deoxyarbutin) →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 5 fields

Name

4-[(Oxan-2-yl)oxy]phenol

CAS Number

53936-56-4

Molecular Formula

C11H14O3

InChI Key

GFBCWCDNXDKFRH-UHFFFAOYSA-N

Monoisotopic Mass

194.094294

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records

Bleaching agent

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 34 of 34 studies

Value	Unit	Endpoint	Route	Species	Source
=15	mg/kg/day	-	-	rat	Regulatory source
=20	mg/kg/day	-	oral	rat	Regulatory source
=74	mg/kg/day	-	dermal	rat	Regulatory source
316	mg/kg bw	-	dermal	rat	Regulatory source
316	mg/kg bw	-	oral	rat	Regulatory source
RG969BY5EN	UNII	FDA UNII substance identifier	-	-	openFDA substances
=0.0218	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=0.77	mg/kg	NOAEL	oral	rat	SCCS Opinion
=3	%	NOAEL	oral	rabbit	SCCS Opinion
=15	mg/kg/day	NOAEL	oral	rat	SCCS Opinion
=20	mg/kg/day	NOAEL	oral	rat	SCCS Opinion
=20	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=25	mg/kg/day	NOAEL	oral	rat	SCCS Opinion
=40	%	NOAEL	dermal	rabbit	SCCS Opinion
=74	mg/kg/day	NOAEL	oral	rat	SCCS Opinion
=75	mg/kg/day	NOAEL	oral	rat	SCCS Opinion
=150	mg/kg/day	NOAEL	-	rat	SCCS Opinion
=316	mg/kg bw	NOAEL	dermal	rat	SCCS Opinion
=800	mg/kg bw	NOAEL	dermal	rabbit	SCCS Opinion
=25	mg/kg/day	developmental toxicity	-	rabbit	Regulatory source
=75	mg/kg/day	developmental toxicity	-	rabbit	Regulatory source
0.0218	mg/kg bw/day	repeated dose toxicity	oral	rat	Regulatory source
=0.77	mg/kg	repeated dose toxicity	oral	rat	Regulatory source
3	%	repeated dose toxicity	oral	rabbit	Regulatory source
20	mg/kg bw/day	repeated dose toxicity	oral	rat	Regulatory source
40	%	repeated dose toxicity	dermal	rabbit	Regulatory source
316	mg/kg bw	repeated dose toxicity	oral	rat	Regulatory source
800	mg/kg bw	repeated dose toxicity	dermal	rabbit	Regulatory source
=15	mg/kg/day	reproductive toxicity	oral	rat	Regulatory source
=20	mg/kg/day	reproductive toxicity	oral	rat	Regulatory source
=25	mg/kg/day	reproductive toxicity	oral	rat	Regulatory source
=74	mg/kg/day	reproductive toxicity	oral	rat	Regulatory source
=75	mg/kg/day	reproductive toxicity	oral	rat	Regulatory source
=150	mg/kg/day	reproductive toxicity	-	rat	Regulatory source

Showing 34 of 34 studies

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1554/15	25 June 2015	insufficient data	Not determined	Skin lightening agent; potential for hydroquinone release; insufficient safety data provided

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL4303145

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 4-[(Oxan-2-yl)oxy]phenol?

4-[(Oxan-2-yl)oxy]phenol has 34 NOAEL studies in the database. The lowest reported value is 15 mg/kg/day in rat. Source: Regulatory source.

Is 4-[(Oxan-2-yl)oxy]phenol used in cosmetics?

Yes, 4-[(Oxan-2-yl)oxy]phenol is also indexed as a cosmetic ingredient under the name Tetrahydropyranyloxy Phenol (Deoxyarbutin). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-[(Oxan-2-yl)oxy]phenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 4-[(Oxan-2-yl)oxy]phenol used outside industrial chemicals?

4-[(Oxan-2-yl)oxy]phenol also appears in cosmetics, pharmaceutical databases.