INCI: TETRAHYDROPYRANYLOXY PHENOL
Tetrahydropyranyloxy Phenol (Deoxyarbutin) (CAS 53936-56-4) is a cosmetic cosmetic ingredient functioning as Skin lightening / Bleaching agent (tyrosinase inhibitor). Reported NOAEL =0.0218 mg/kg bw/day in rat (SCCS Opinion); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 53936-56-4 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydropyranyloxy Phenol (Deoxyarbutin).
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10 study endpoints found for Tetrahydropyranyloxy Phenol (Deoxyarbutin). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =15 mg/kg/day | oral | rat | reproductive toxicity | SCCS Opinion |
| NOAEL | =15 mg/kg/day | oral | rat | reproductive toxicity | SCCS Opinion |
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| UK | banned | - | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 82.04% | - | - | SCCS/1554/15 |
Preliminary editorial summary for Tetrahydropyranyloxy Phenol (Deoxyarbutin) — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Tetrahydropyranyloxy Phenol (Deoxyarbutin) by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg, mg/kg/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 82.04% | SCCS opinion extraction | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Tetrahydropyranyloxy Phenol (Deoxyarbutin) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Tetrahydropyranyloxy Phenol (Deoxyarbutin) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Tetrahydropyranyloxy Phenol (Deoxyarbutin) functions as: Skin lightening / Bleaching agent (tyrosinase inhibitor). It is classified as a cosmetic ingredient in our database. CAS number: 53936-56-4.
The NOAEL (No Observed Adverse Effect Level) for Tetrahydropyranyloxy Phenol (Deoxyarbutin) is =0.0218 mg/kg bw/day based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Tetrahydropyranyloxy Phenol (Deoxyarbutin) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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