What is the NOAEL for Ammonium glycyrrhizate?
Ammonium glycyrrhizate has 14 NOAEL studies in the database. The lowest reported value is 3VRD35U26C UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ammonium glycyrrhizate
Also known as: Ammonium glycyrrhizinate (alpha-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt), alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniate, alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammonium salt (1:1), alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, monoammonium salt, Ammoniated glycyrrhizin (+14 more)
CAS 53956-04-0
Ammonium glycyrrhizate (CAS 53956-04-0) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Ammonium glycyrrhizate
CAS Number
53956-04-0
DTXSID
DTXSID2041204
Molecular Formula
C42H62O16.H3N
InChI Key
ILRKKHJEINIICQ-OOFFSTKBSA-N
Monoisotopic Mass
839.430335
Synonyms
Ammonium glycyrrhizinate (alpha-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt)alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniatealpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammonium salt (1:1)alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, monoammonium saltAmmoniated glycyrrhizinEINECS 258-887-7FEMA No. 2528alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-GlycamilGlycyrramGlycyrrhizic acid, ammonium saltGlycyrrhizin, ammoniated (Glycyrrhiza spp.)
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
19 records
Flavouring and nutrientDeodorizerSoftener and conditionerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3VRD35U26C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3VRD35U26C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3VRD35U26C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3VRD35U26C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 90 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 680 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 700 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 800 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1230 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1870 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ammonium glycyrrhizate | 258-887-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
5%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
41
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ammonium glycyrrhizate?
Ammonium glycyrrhizate appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Europe, IFRA Transparency, and 1 more. Source: EPA CPDat.
Is Ammonium glycyrrhizate used in cosmetics?
Yes, Ammonium glycyrrhizate is also indexed as a cosmetic ingredient under the name Ammonium Glycyrrhizate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ammonium glycyrrhizate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ammonium glycyrrhizate used outside industrial chemicals?
Ammonium glycyrrhizate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.