Is Ammonium Glycyrrhizate safe in cosmetics?
Ammonium Glycyrrhizate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Ammonium Glycyrrhizate
Also known as: Ammonium glycyrrhizinate (alpha-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt), alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniate, alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammonium salt (1:1), alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, monoammonium salt, Ammoniated glycyrrhizin (+14 more)
INCI: AMMONIUM GLYCYRRHIZATE
Ammonium Glycyrrhizate (CAS 53956-04-0) is a cosmetic active ingredient functioning as skin conditioning, anti-inflammatory, soothing, flavouring, fragrance. EU Regulation 1223/2009 status: permitted, max 5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 53956-04-0 →
Auto-generated CPSR Part A draft with source citations
Function
skin conditioning, anti-inflammatory, soothing, flavouring, fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid;azane
InChIKey
ILRKKHJEINIICQ-OOFFSTKBSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
5%
US US Status
permitted
US Notes
CIR 2007 concluded safe as used; licorice derivatives hold GRAS status as direct food ingredients with oral glycyrrhizic acid limits; European SCF recommended ≤100 mg/day oral intake (food context only, not relevant to cosmetics given negligible dermal absorption); no FDA cosmetic restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ammonium Glycyrrhizate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Ammonium Glycyrrhizate.
Regulatory Flags
eye-irritant-clp-h319
cosmos-eligible
no-sccs-opinion
ifra_fragrance
fda_food_additive
Known Synonyms
Ammonium glycyrrhizinate (alpha-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt)
alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniate
alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammonium salt (1:1)
alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, monoammonium salt
Ammoniated glycyrrhizin
EINECS 258-887-7
FEMA No. 2528
alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-
Glycamil
Glycyrram
Glycyrrhizic acid, ammonium salt
Glycyrrhizin, ammoniated (Glycyrrhiza spp.)
Glycyrrhizinic acid, ammonium salt (1:1)
Monoammonium (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosidu
Monoammonium glycyrrhizate
Monoammonium glycyrrhizinate
UNII-3VRD35U26C
Ammonium glycyrrhizinate
ammonium-glycyrrhizinate
Chemical Function
Flavouring and nutrient
Deodorizer
Softener and conditioner
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
41
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
Food Category
flavoring
Frequently Asked Questions
Is Ammonium Glycyrrhizate allowed in the EU?
Ammonium Glycyrrhizate EU regulatory status: permitted. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Ammonium Glycyrrhizate do in cosmetics?
Ammonium Glycyrrhizate functions as: skin conditioning, anti-inflammatory, soothing, flavouring, fragrance. It is classified as a Active Ingredient in our database. CAS number: 53956-04-0.
Is Ammonium Glycyrrhizate used outside cosmetics?
Ammonium Glycyrrhizate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ammonium Glycyrrhizate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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