Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Ammonium Glycyrrhizate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 800 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 680 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 700 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Well-characterized, CIR-cleared ingredient with strong anti-inflammatory and soothing efficacy profile. CIR supports up to 5% use concentration with good safety margin given negligible dermal absorption. Eye irritation CLP classification is a manufacturing/occupational hazard designation, not a cosmetic restriction. Use CIR 2007 final report as primary safety dossier reference. COSMOS/ECOCERT eligible if plant-derived from Glycyrrhiza glabra. Suitable for aqueous phase incorporation.
Regulatory Flags
Frequently Asked Questions
Is Ammonium Glycyrrhizate safe in cosmetics?
Well-characterized, CIR-cleared ingredient with strong anti-inflammatory and soothing efficacy profile. CIR supports up to 5% use concentration with good safety margin given negligible dermal absorption. Eye irritation CLP classification is a manufacturing/occupational hazard designation, not a cosmetic restriction. Use CIR 2007 final report as primary safety dossier reference. COSMOS/ECOCERT eligible if plant-derived from Glycyrrhiza glabra. Suitable for aqueous phase incorporation. The EU classifies Ammonium Glycyrrhizate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Ammonium Glycyrrhizate allowed in the EU?
Ammonium Glycyrrhizate EU regulatory status: permitted. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Ammonium Glycyrrhizate do in cosmetics?
Ammonium Glycyrrhizate functions as: skin conditioning, anti-inflammatory, soothing, flavouring, fragrance. It is classified as a Active Ingredient in our database. CAS number: 53956-04-0.
What is the Margin of Safety for Ammonium Glycyrrhizate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ammonium Glycyrrhizate?
The NOAEL (No Observed Adverse Effect Level) for Ammonium Glycyrrhizate is 500 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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