NOAEL Data REACH Registered Cosmetic Ingredient

Sodium salicylate

Also known as: Benzoic acid, 2-hydroxy-, monosodium salt, Sodium salicylic acid, Diuretin, EINECS 200-198-0, Idocyl novum (+7 more)

CAS 54-21-7

Sodium salicylate (CAS 54-21-7) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.

View cosmetic safety profile for Sodium Salicylate →

Cross-Vertical Regulatory Divergence

Sodium salicylate is classified GHS CMR hazard (H302, H319, H361, H361d) in the chemicals database but is restricted in EU cosmetics at max 0.5% (as acid) preservative (Annex V/3); 2.0% other / 3.0% rinse-off hair (Annex III).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

Sodium salicylate

CAS Number

54-21-7

Molecular Formula

C7H6O3.Na

InChI Key

ABBQHOQBGMUPJH-UHFFFAOYSA-M

Synonyms

Benzoic acid, 2-hydroxy-, monosodium saltSodium salicylic acidDiuretinEINECS 200-198-0Idocyl novumMonosodium 2-hydroxybenzoateNSC 202167Parbocyl-revSalicylic acid, sodium saltNatrium salicylatUNII-WIQ1H85SYPNatrum salicylicum

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records

Preservative

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Europe; Personal care - body hygiene - hand soap	Danish Environmental Protection Agency	Danish EPA
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
Europe; Personal care - hair styling and care - shampoo-dandruff	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 31 of 31 studies

Value	Unit	Endpoint	Route	Species	Source
=1.32	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
83.7	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP ICE eye irritation
1	unitless	EPA Classification	Ocular	Rabbit	NTP ICE eye irritation
WIQ1H85SYP	UNII	FDA UNII substance identifier	-	-	openFDA substances
1.01	%/sec	Intensity	Ocular	-	NTP ICE eye irritation
=200	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=930	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1000	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=2000	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=200	mg/kg bw/day	LEL	oral	Rat	ECHA
=2000	mg/kg bw/day	LEL	oral	Rat	ECHA
<=200	mg/kg bw/day	LOAEL	oral	Rat	ECHA
<=218	mg/kg bw/day	LOAEL	oral	Rat	ECHA
=300	mg/kg bw/day	LOAEL	oral	Rat	ECHA
=800	mg/kg bw/day	LOAEL	oral	Mouse	ECHA
=1500	mg/kg bw/day	LOAEL	oral	Mouse	ECHA
=1600	mg/kg bw/day	LOAEL	oral	Mouse	ECHA
=700	mg/kg bw/day	LOEL	oral	Rat	ToxValDB ECOTOX
0	s	Lag time	Ocular	-	NTP ICE eye irritation
=30	mg/kg bw/day	NOAEL	oral	Rat	ECHA
>=80	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=90	mg/kg bw/day	NOAEL	oral	Rat	ECHA
>=138	mg/kg bw/day	NOAEL	oral	Rat	ECHA
>=200	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=800	mg/kg bw/day	NOAEL	oral	Mouse	ECHA
=100	mg/L	NOEC	environmental	Rat	ToxValDB ECOTOX
=200	mg/L	NOEC	environmental	Rat	ToxValDB ECOTOX
=300	mg/L	NOEC	environmental	Rat	ToxValDB ECOTOX
=400	mg/L	NOEC	environmental	Rat	ToxValDB ECOTOX
=1000	mg/L	NOEC	environmental	Rat	ToxValDB ECOTOX
60	%	Plateau level	Ocular	-	NTP ICE eye irritation

Showing 31 of 31 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Sodium salicylate	200-198-0	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.5% (as acid) preservative (Annex V/3); 2.0% other / 3.0% rinse-off hair (Annex III)

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed SODIUM SALICYLATE

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Sodium salicylate?

Sodium salicylate has 31 NOAEL studies in the database. The lowest reported value is 1 unitless via Ocular in Rabbit. Source: NTP ICE eye irritation.

What regulatory lists include Sodium salicylate?

Sodium salicylate appears on 7 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Europe; Personal care - body hygiene - hand soap, CEDI, and 4 more. Source: EPA CPDat.

Is Sodium salicylate used in cosmetics?

Yes, Sodium salicylate is also indexed as a cosmetic ingredient under the name Sodium Salicylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sodium salicylate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Sodium salicylate have different safety status in cosmetics vs industrial chemicals?

Is Sodium salicylate used outside industrial chemicals?

Sodium salicylate also appears in cosmetics, pharmaceutical databases.