Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Sodium Salicylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=138 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1000 ppm | oral | rat | oral | REACH |
| LOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=150 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 400 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 300 mg/kg bw/day | oral | dog | oral | REACH |
Expert Verdict
Safe at 0.5% (as acid) preservative; 2% leave-on / 3% rinse-off hair. Not for children under 3 years except shampoo. Label warning required. Dissociates to salicylic acid; total salicylate equivalents must not exceed limits.
Regulatory Flags
Frequently Asked Questions
Is Sodium Salicylate safe in cosmetics?
Safe at 0.5% (as acid) preservative; 2% leave-on / 3% rinse-off hair. Not for children under 3 years except shampoo. Label warning required. Dissociates to salicylic acid; total salicylate equivalents must not exceed limits. The EU classifies Sodium Salicylate as "restricted". Safety rating: GOOD. 7 toxicological study endpoint(s) are available in our database.
Is Sodium Salicylate allowed in the EU?
Sodium Salicylate EU regulatory status: restricted. Maximum allowed concentration: 0.5% (as acid) preservative (Annex V/3); 2.0% other / 3.0% rinse-off hair (Annex III). This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Salicylate do in cosmetics?
Sodium Salicylate functions as: Denaturant, Preservative, Hair/Skin Conditioning. It is classified as a Preservative in our database. CAS number: 54-21-7.
What is the Margin of Safety for Sodium Salicylate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Salicylate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Salicylate is >=138 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.
Compliance Tools
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