What is the NOAEL for Propafenone?
Propafenone has 8 NOAEL studies in the database. The lowest reported value is 38.94 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Propafenone
Also known as: EINECS 258-955-6, 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone, Propafenonum, UNII-68IQX3T69U, 2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone
CAS 54063-53-5
Propafenone (CAS 54063-53-5) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Propafenone is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Propafenone
CAS Number
54063-53-5
DTXSID
DTXSID9045184
Molecular Formula
C21H27NO3
InChI Key
JWHAUXFOSRPERK-UHFFFAOYSA-N
Monoisotopic Mass
341.199094
Synonyms
EINECS 258-955-61-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanonePropafenonumUNII-68IQX3T69U2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 38.94 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 2287 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| 68IQX3T69U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68IQX3T69U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68IQX3T69U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68IQX3T69U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.022 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| 0.04 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Propafenone | 258-955-6 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PROPAFENONE
ChEMBL Phase
4
Adverse Events
107
Bioactivity
38
Frequently Asked Questions
What regulatory lists include Propafenone?
Propafenone appears on 2 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Propafenone used in cosmetics?
Yes, Propafenone is also indexed as a cosmetic ingredient under the name Propafenone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Propafenone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Propafenone have different safety status in cosmetics vs industrial chemicals?
Propafenone is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
Is Propafenone used outside industrial chemicals?
Propafenone also appears in cosmetics, pharmaceutical databases.