Is Propafenone safe in cosmetics?
Propafenone has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
Propafenone
Also known as: EINECS 258-955-6, 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone, Propafenonum, UNII-68IQX3T69U, 2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone
INCI: NOT AN INCI-LISTED COSMETIC INGREDIENT
Propafenone (CAS 54063-53-5) is a cosmetic cosmetic ingredient functioning as Class IC antiarrhythmic drug (pharmaceutical ONLY). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 54063-53-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Propafenone is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Class IC antiarrhythmic drug (pharmaceutical ONLY)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
InChIKey
JWHAUXFOSRPERK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Prescription drug only (Rythmol®); absolutely NOT permitted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Propafenone.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Expert Verdict
Expert safety assessment and concern-level summary for Propafenone.
Known Synonyms
EINECS 258-955-6
1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone
Propafenonum
UNII-68IQX3T69U
2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PROPAFENONE
ChEMBL ID
CHEMBL631
Max Phase
4
Adverse Event Associations
107
Frequently Asked Questions
Is Propafenone allowed in the EU?
Propafenone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Propafenone do in cosmetics?
Propafenone functions as: Class IC antiarrhythmic drug (pharmaceutical ONLY). It is classified as a cosmetic ingredient in our database. CAS number: 54063-53-5.
Is Propafenone used outside cosmetics?
Propafenone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Propafenone have different safety status in cosmetics vs industrial chemicals?
Propafenone is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
Compliance Tools
Check Propafenone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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