What is the NOAEL for Hexamethylcyclotrisiloxane?
Hexamethylcyclotrisiloxane has 5 NOAEL studies in the database. The lowest reported value is 110 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexamethylcyclotrisiloxane
Also known as: Benzenemethanol, α-(1-aminoethyl)-, hydrochloride
CAS 541-05-9
Hexamethylcyclotrisiloxane (CAS 541-05-9) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Hexamethylcyclotrisiloxane is classified GHS Danger (H228) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
7 fields
Name
Hexamethylcyclotrisiloxane
CAS Number
541-05-9
DTXSID
DTXSID6027185
Molecular Formula
C6H18O3Si3
InChI Key
HTDJPCNNEPUOOQ-UHFFFAOYSA-N
Monoisotopic Mass
222.056374
Synonyms
Benzenemethanol, α-(1-aminoethyl)-, hydrochloride
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
10 records
SolventSoftener and conditioner
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =110 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| EPV75L8O0R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EPV75L8O0R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EPV75L8O0R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EPV75L8O0R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexamethylcyclotrisiloxane | 208-765-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3182063
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is Hexamethylcyclotrisiloxane used in cosmetics?
Yes, Hexamethylcyclotrisiloxane is also indexed as a cosmetic ingredient under the name CYCLOTRISILOXANE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexamethylcyclotrisiloxane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Hexamethylcyclotrisiloxane have different safety status in cosmetics vs industrial chemicals?
Hexamethylcyclotrisiloxane is classified GHS Danger (H228) in the chemicals database but is allowed in EU cosmetics.
Is Hexamethylcyclotrisiloxane used outside industrial chemicals?
Hexamethylcyclotrisiloxane also appears in cosmetics, pharmaceutical databases.